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. 2023 Oct 17;11(10):1604. doi: 10.3390/vaccines11101604

Figure 4.

Figure 4

Functional responses of Vδ2 cells after IV BCG vaccination. (a) Intracellular cytokine staining (ICS) was utilised to determine the proportion of Vδ2 cells producing IFN-γ, TNF-α or IL-17. Each value represents results from ex vivo BCG-stimulated cells minus results from cells without ex vivo stimulation. (b) Vδ2 production of IFN-γ, TNF-α or IL-17 as a proportion of all CD3+ cells producing these cytokines. (c) Log2 fold change in the proportion of Vδ2 cells expressing CD107a or producing granulysin or granzyme B, from baseline. Shown are results without any ex vivo stimulation, and with an ex vivo BCG stimulation, minus results from unstimulated cells. Each dot represents results from an individual. Asterisks represent significant differences between indicated timepoints, determined with Wilcoxon tests (p < 0.05). (d) Spearman correlation tests were carried out to assess whether the proportion of functional Vδ2 cells in the circulation was associated with TB disease or health measures. p-values and r values are displayed on the graphs.