The correlation between circRNAs with the cell composition of TAAD is depicted. (A–D) TAAD aortic tissue and healthy control were assessed, and different cells, including immune cells (A), stromal cells (B), HSC (C), and epithelial cells (D), were studied. (E) Heatmap of Spearman’s correlation of circRNA expression and different cell scores. (F) Heatmap of Spearman’s correlation of circRNA expression and VSMC score. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 (Student’s t-test and Spearman’s correlation) [124,125,126,127,128,129,130,131,132,133,134,135,136,137,138]. From Liang Q et al. Front Cardiovasc Med. 2023 Jan 13; 9:1074835.