Table 6. Seriousness, time of onset, outcome at two to less than four weeks following diarrhoea and other adverse drug reactions, and time to recovery or remission.
ADR, adverse drug reaction.
| Category | Type of ADR | n (%) | Seriousness | Time of onset | Outcome | Time to recovery or remission | ||||||||||||||||||
| Serious | Non-serious | <1 week | 1–<2 weeks | 2–<4 weeks | 4–<6 weeks | 6–<8 weeks | 8–<10 weeks | 10–<12 weeks | ≥12 weeks | Recovered | Recovering | Recovered + recovering | Not recovered | Sequelae | Death | Unknown | 1-3 days | 4-7 days | 8-14 days | ≥15 days | ||||
| Total | Diarrhoea | 107 (100) | 2 (1.9) | 105 (98.1) | 64 (59.8) | 15 (14.0) | 18 (16.8) | 5 (4.7) | 2 (1.9) | 2 (1.9) | 0 (0.0) | 1 (0.9) | 77 (72.0) | 24 (22.4) | 101 (94.4) | 3 (2.8) | 0 (0.0) | 0 (0.0) | 3 (2.8) | 43 (40.2) | 26 (24.3) | 15 (14.0) | 17 (15.9) | |
| Other | 38 (100) | 7 (18.4) | 31 (81.6) | 16 (42.1) | 8 (21.1) | 8 (21.1) | 4 (10.5) | 1 (2.6) | 1 (2.6) | 0 (0.0) | 0 (0.0) | 18 (47.4) | 16 (42.1) | 34 (89.5) | 3 (7.9) | 0 (0.0) | 0 (0.0) | 1 (2.6) | 11 (28.9) | 7 (18.4) | 8 (21.1) | 8 (21.1) | ||
| Age (years) | ||||||||||||||||||||||||
| <75 | Diarrhoea | 74 (100) | 1 (1.4) | 73 (98.6) | 43 (58.1) | 9 (12.2) | 14 (18.9) | 4 (5.4) | 2 (2.7) | 1 (1.4) | 0 (0.0) | 1 (1.4) | 54 (73.0) | 15 (20.3) | 69 (93.2) | 2 (2.7) | 0 (0.0) | 0 (0.0) | 3 (4.1) | 30 (40.5) | 16 (21.6) | 12 (16.2) | 11 (14.9) | |
| Other | 27 (100) | 4 (14.8) | 23 (85.2) | 10 (37.0) | 6 (22.2) | 7 (25.9) | 3 (11.1) | 1 (3.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 13 (48.1) | 12 (44.4) | 25 (92.6) | 2 (7.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 7 (25.9) | 7 (25.9) | 4 (14.8) | 7 (25.9) | ||
| ≥75 | Diarrhoea | 33 (100) | 1 (3.0) | 32 (97.0) | 21 (63.6) | 6 (18.2) | 4 (12.1) | 1 (3.0) | 0 (0.0) | 1 (3.0) | 0 (0.0) | 0 (0.0) | 23 (69.7) | 9 (27.3) | 32 (97.0) | 1 (3.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 13 (39.4) | 10 (30.3) | 3 (9.1) | 6 (18.2) | |
| Other | 11 (100) | 3 (27.3) | 8 (72.7) | 6 (54.5) | 2 (18.2) | 1 (9.1) | 1 (9.1) | 0 (0.0) | 1 (9.1) | 0 (0.0) | 0 (0.0) | 5 (45.5) | 4 (36.4) | 9 (81.8) | 1 (9.1) | 0 (0.0) | 0 (0.0) | 1 (9.1) | 4 (36.4) | 0 (0.0) | 4 (36.4) | 1 (9.1) | ||
| Performance status (PS) | ||||||||||||||||||||||||
| 0-2 | Diarrhoea | 78 (100) | 2 (2.6) | 76 (97.4) | 46 (59.0) | 10 (12.8) | 15 (19.2) | 3 (3.8) | 2 (2.6) | 1 (1.3) | 0 (0.0) | 1 (1.3) | 57 (73.1) | 17 (21.8) | 74 (94.9) | 1 (1.3) | 0 (0.0) | 0 (0.0) | 3 (3.8) | 29 (37.2) | 17 (21.8) | 13 (16.7) | 15 (19.2) | |
| Other | 30 (100) | 5 (16.7) | 25 (83.3) | 12 (40.0) | 7 (23.3) | 7 (23.3) | 3 (10.0) | 1 (3.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 15 (50.0) | 12 (40.0) | 27 (90.0) | 2 (6.7) | 0 (0.0) | 0 (0.0) | 1 (3.3) | 9 (30.0) | 5 (16.7) | 6 (20.0) | 7 (23.3) | ||
| 3-4 | Diarrhoea | 29 (100) | 0 (0.0) | 29 (100) | 18 (62.1) | 5 (17.2) | 3 (10.3) | 2 (6.9) | 0 (0.0) | 1 (3.4) | 0 (0.0) | 0 (0.0) | 20 (69.0) | 7 (24.1) | 27 (93.1) | 2 (6.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 14 (48.3) | 9 (31.0) | 2 (6.9) | 2 (6.9) | |
| Other | 8 (100) | 2 (25.0) | 6 (75.0) | 4 (50.0) | 1 (12.5) | 1 (12.5) | 1 (12.5) | 0 (0.0) | 1 (12.5) | 0 (0.0) | 0 (0.0) | 3 (37.5) | 4 (50.0) | 7 (87.5) | 1 (12.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (25.0) | 2 (25.0) | 2 (25.0) | 1 (12.5) | ||
| Severity of constipation before naldemedine dosing | ||||||||||||||||||||||||
| Mild | Diarrhoea | 20 (100) | 1 (5.0) | 19 (95.0) | 9 (45.0) | 6 (30.0) | 3 (15.0) | 0 (0.0) | 2 (10.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 14 (70.0) | 6 (30.0) | 20 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 8 (40.0) | 3 (15.0) | 5 (25.0) | 4 (20.0) | |
| Other | 14 (100) | 4 (28.6) | 10 (71.4) | 6 (42.9) | 4 (28.6) | 2 (14.3) | 1 (7.1) | 1 (7.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 5 (35.7) | 9 (64.3) | 14 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (21.4) | 2 (14.3) | 5 (35.7) | 4 (28.6) | ||
| Moderate | Diarrhoea | 60 (100) | 0 (0.0) | 60 (100) | 40 (66.7) | 9 (15.0) | 6 (10.0) | 3 (5.0) | 0 (0.0) | 1 (1.7) | 0 (0.0) | 1 (1.7) | 46 (76.7) | 11 (18.3) | 57 (95.0) | 1 (1.7) | 0 (0.0) | 0 (0.0) | 2 (3.3) | 23 (38.3) | 16 (26.7) | 7 (11.7) | 11 (18.3) | |
| Other | 15 (100) | 2 (13.3) | 13 (86.7) | 7 (46.7) | 3 (20.0) | 3 (20.0) | 2 (13.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 7 (46.7) | 5 (33.3) | 12 (80.0) | 2 (13.3) | 0 (0.0) | 0 (0.0) | 1 (6.7) | 4 (26.7) | 2 (13.3) | 2 (13.3) | 4 (26.7) | ||
| Severe | Diarrhoea | 17 (100) | 0 (0.0) | 17 (100) | 12 (70.6) | 0 (0.0) | 4 (23.5) | 0 (0.0) | 0 (0.0) | 1 (5.9) | 0 (0.0) | 0 (0.0) | 12 (70.6) | 4 (23.5) | 16 (94.1) | 1 (5.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 12 (70.6) | 2 (11.8) | 1 (5.9) | 1 (5.9) | |
| Other | 8 (100) | 1 (12.5) | 7 (87.5) | 3 (37.5) | 1 (12.5) | 3 (37.5) | 0 (0.0) | 0 (0.0) | 1 (12.5) | 0 (0.0) | 0 (0.0) | 6 (75.0) | 1 (12.5) | 7 (87.5) | 1 (12.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (37.5) | 3 (37.5) | 1 (12.5) | 0 (0.0) | ||
| Brain metastasis | ||||||||||||||||||||||||
| No | Diarrhoea | 102 (100) | 2 (2.0) | 100 (98.0) | 60 (58.8) | 15 (14.7) | 18 (17.6) | 4 (3.9) | 2 (2.0) | 2 (2.0) | 0 (0.0) | 1 (1.0) | 74 (72.5) | 23 (22.5) | 97 (95.1) | 3 (2.9) | 0 (0.0) | 0 (0.0) | 2 (2.0) | 40 (39.2) | 25 (24.5) | 15 (14.7) | 17 (16.7) | |
| Other | 32 (100) | 7 (21.9) | 25 (78.1) | 15 (46.9) | 7 (21.9) | 5 (15.6) | 3 (9.4) | 1 (3.1) | 1 (3.1) | 0 (0.0) | 0 (0.0) | 17 (53.1) | 13 (40.6) | 30 (93.8) | 1 (3.1) | 0 (0.0) | 0 (0.0) | 1 (3.1) | 10 (31.3) | 6 (18.8) | 7 (21.9) | 7 (21.9) | ||
| Yes | Diarrhoea | 5 (100) | 0 (0.0) | 5 (100) | 4 (80.0) | 0 (0.0) | 0 (0.0) | 1 (20.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (60.0) | 1 (20.0) | 4 (80.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (20.0) | 3 (60.0) | 1 (20.0) | 0 (0.0) | 0 (0.0) | |
| Other | 6 (100) | 0 (0.0) | 6 (100) | 1 (16.7) | 1 (16.7) | 3 (50.0) | 1 (16.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (16.7) | 3 (50.0) | 4 (66.7) | 2 (33.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (16.7) | 1 (16.7) | 1 (16.7) | 1 (16.7) | ||
| Anticancer drug treatment | ||||||||||||||||||||||||
| No | Diarrhoea | 51 (100) | 0 (0.0) | 51 (100) | 36 (70.6) | 4 (7.8) | 7 (13.7) | 2 (3.9) | 1 (2.0) | 0 (0.0) | 0 (0.0) | 1 (2.0) | 36 (70.6) | 13 (25.5) | 49 (96.1) | 1 (2.0) | 0 (0.0) | 0 (0.0) | 1 (2.0) | 23 (45.1) | 14 (27.5) | 6 (11.8) | 6 (11.8) | |
| Other | 19 (100) | 3 (15.8) | 16 (84.2) | 10 (52.6) | 4 (21.1) | 3 (15.8) | 1 (5.3) | 1 (5.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 11 (57.9) | 8 (42.1) | 19 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 6 (31.6) | 6 (31.6) | 3 (15.8) | 4 (21.1) | ||
| Yes | Diarrhoea | 56 (100) | 2 (3.6) | 54 (96.4) | 28 (50.0) | 11 (19.6) | 11 (19.6) | 3 (5.4) | 1 (1.8) | 2 (3.6) | 0 (0.0) | 0 (0.0) | 41 (73.2) | 11 (19.6) | 52 (92.9) | 2 (3.6) | 0 (0.0) | 0 (0.0) | 2 (3.6) | 20 (35.7) | 12 (21.4) | 9 (16.1) | 11 (19.6) | |
| Other | 19 (100) | 4 (21.1) | 15 (78.9) | 6 (31.6) | 4 (21.1) | 5 (26.3) | 3 (15.8) | 0 (0.0) | 1 (5.3) | 0 (0.0) | 0 (0.0) | 7 (36.8) | 8 (42.1) | 15 (78.9) | 3 (15.8) | 0 (0.0) | 0 (0.0) | 1 (5.3) | 5 (26.3) | 1 (5.3) | 5 (26.3) | 4 (21.1) | ||
| Opioid analgesics used when naldemedine was started | ||||||||||||||||||||||||
| Fentanyl only | Diarrhoea | 5 (100) | 0 (0.0) | 5 (100) | 5 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (80.0) | 1 (20.0) | 5 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (40.0) | 1 (20.0) | 1 (20.0) | 1 (20.0) | |
| Other | 1 (100) | 0 (0.0) | 1 (100) | 0 (0.0) | 0 (0.0) | 1 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100) | 0 (0.0) | 1 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100) | 0 (0.0) | ||
| Only strong opioids other than fentanyl | Diarrhoea | 72 (100) | 2 (2.8) | 70 (97.2) | 43 (59.7) | 10 (13.9) | 10 (13.9) | 5 (6.9) | 1 (1.4) | 2 (2.8) | 0 (0.0) | 1 (1.4) | 50 (69.4) | 18 (25.0) | 68 (94.4) | 2 (2.8) | 0 (0.0) | 0 (0.0) | 2 (2.8) | 30 (41.7) | 16 (22.2) | 10 (13.9) | 12 (16.7) | |
| Other | 29 (100) | 5 (17.2) | 24 (82.8) | 14 (48.3) | 5 (17.2) | 5 (17.2) | 3 (10.3) | 1 (3.4) | 1 (3.4) | 0 (0.0) | 0 (0.0) | 12 (41.4) | 13 (44.8) | 25 (86.2) | 3 (10.3) | 0 (0.0) | 0 (0.0) | 1 (3.4) | 8 (27.6) | 6 (20.7) | 6 (20.7) | 5 (17.2) | ||
| Weak opioids only | Diarrhoea | 12 (100) | 0 (0.0) | 12 (100) | 8 (66.7) | 0 (0.0) | 4 (33.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 7 (58.3) | 4 (33.3) | 11 (91.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (8.3) | 4 (33.3) | 3 (25.0) | 1 (8.3) | 3 (25.0) | |
| Other | 2 (100) | 0 (0.0) | 2 (100) | 1 (50.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 2 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | ||
| Others | Diarrhoea | 18 (100) | 0 (0.0) | 18 (100) | 8 (44.4) | 5 (27.8) | 4 (22.2) | 0 (0.0) | 1 (5.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 16 (88.9) | 1 (5.6) | 17 (94.4) | 1 (5.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 7 (38.9) | 6 (33.3) | 3 (16.7) | 1 (5.6) | |
| Other | 6 (100) | 2 (33.3) | 4 (66.7) | 1 (16.7) | 2 (33.3) | 2 (33.3) | 1 (16.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (66.7) | 2 (33.3) | 6 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (33.3) | 1 (16.7) | 1 (16.7) | 2 (33.3) | ||
| Previously used laxatives | ||||||||||||||||||||||||
| Osmotic/saline laxatives only | Diarrhoea | 43 (100) | 1 (2.3) | 42 (97.7) | 23 (53.5) | 11 (25.6) | 6 (14.0) | 1 (2.3) | 1 (2.3) | 0 (0.0) | 0 (0.0) | 1 (2.3) | 31 (72.1) | 11 (25.6) | 42 (97.7) | 1 (2.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 15 (34.9) | 9 (20.9) | 9 (20.9) | 9 (20.9) | |
| Other | 15 (100) | 2 (13.3) | 13 (86.7) | 10 (66.7) | 1 (6.7) | 3 (20.0) | 1 (6.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 8 (53.3) | 7 (46.7) | 15 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (26.7) | 3 (20.0) | 6 (40.0) | 2 (13.3) | ||
| Stimulant laxatives only | Diarrhoea | 8 (100) | 0 (0.0) | 8 (100) | 5 (62.5) | 2 (25.0) | 0 (0.0) | 0 (0.0) | 1 (12.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 7 (87.5) | 1 (12.5) | 8 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 5 (62.5) | 2 (25.0) | 0 (0.0) | 1 (12.5) | |
| Other | 2 (100) | 0 (0.0) | 2 (100) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 2 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | ||
| Others | Diarrhoea | 35 (100) | 0 (0.0) | 35 (100) | 27 (77.1) | 2 (5.7) | 4 (11.4) | 2 (5.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 27 (77.1) | 7 (20.0) | 34 (97.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.9) | 14 (40.0) | 11 (31.4) | 4 (11.4) | 5 (14.3) | |
| Other | 13 (100) | 1 (7.7) | 12 (92.3) | 3 (23.1) | 5 (38.5) | 4 (30.8) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 6 (46.2) | 4 (30.8) | 10 (76.9) | 2 (15.4) | 0 (0.0) | 0 (0.0) | 1 (7.7) | 3 (23.1) | 3 (23.1) | 2 (15.4) | 2 (15.4) | ||
| Nothing | Diarrhoea | 21 (100) | 1 (4.8) | 20 (95.2) | 9 (42.9) | 0 (0.0) | 8 (38.1) | 2 (9.5) | 0 (0.0) | 2 (9.5) | 0 (0.0) | 0 (0.0) | 12 (57.1) | 5 (23.8) | 17 (81.0) | 2 (9.5) | 0 (0.0) | 0 (0.0) | 2 (9.5) | 9 (42.9) | 4 (19.0) | 2 (9.5) | 2 (9.5) | |
| Other | 8 (100) | 4 (50.0) | 4 (50.0) | 3 (37.5) | 1 (12.5) | 0 (0.0) | 3 (37.5) | 0 (0.0) | 1 (12.5) | 0 (0.0) | 0 (0.0) | 3 (37.5) | 4 (50.0) | 7 (87.5) | 1 (12.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (37.5) | 0 (0.0) | 0 (0.0) | 4 (50.0) | ||
| Concomitant laxatives | ||||||||||||||||||||||||
| Osmotic/saline laxatives only | Diarrhoea | 40 (100) | 1 (2.5) | 39 (97.5) | 22 (55.0) | 8 (20.0) | 7 (17.5) | 2 (5.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.5) | 28 (70.0) | 11 (27.5) | 39 (97.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.5) | 12 (30.0) | 8 (20.0) | 9 (22.5) | 10 (25.0) | |
| Other | 16 (100) | 2 (12.5) | 14 (87.5) | 10 (62.5) | 1 (6.3) | 3 (18.8) | 2 (12.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 9 (56.3) | 7 (43.8) | 16 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (25.0) | 3 (18.8) | 6 (37.5) | 3 (18.8) | ||
| Stimulant laxatives only | Diarrhoea | 7 (100) | 0 (0.0) | 7 (100) | 4 (57.1) | 1 (14.3) | 0 (0.0) | 0 (0.0) | 2 (28.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 6 (85.7) | 1 (14.3) | 7 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 5 (71.4) | 1 (14.3) | 0 (0.0) | 1 (14.3) | |
| Other | 2 (100) | 0 (0.0) | 2 (100) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 2 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | ||
| Others | Diarrhoea | 44 (100) | 0 (0.0) | 44 (100) | 28 (63.6) | 6 (13.6) | 5 (11.4) | 3 (6.8) | 0 (0.0) | 2 (4.5) | 0 (0.0) | 0 (0.0) | 34 (77.3) | 7 (15.9) | 41 (93.2) | 2 (4.5) | 0 (0.0) | 0 (0.0) | 1 (2.3) | 17 (38.6) | 14 (31.8) | 5 (11.4) | 5 (11.4) | |
| Other | 18 (100) | 4 (22.2) | 14 (77.8) | 4 (22.2) | 6 (33.3) | 4 (22.2) | 2 (11.1) | 1 (5.6) | 1 (5.6) | 0 (0.0) | 0 (0.0) | 7 (38.9) | 7 (38.9) | 14 (77.8) | 3 (16.7) | 0 (0.0) | 0 (0.0) | 1 (5.6) | 5 (27.8) | 3 (16.7) | 2 (11.1) | 4 (22.2) | ||
| Nothing | Diarrhoea | 16 (100) | 1 (6.3) | 15 (93.8) | 10 (62.5) | 0 (0.0) | 6 (37.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 9 (56.3) | 5 (31.3) | 14 (87.5) | 1 (6.3) | 0 (0.0) | 0 (0.0) | 1 (6.3) | 9 (56.3) | 3 (18.8) | 1 (6.3) | 1 (6.3) | |
| Other | 2 (100.0) | 1 (50.0) | 1 (50.0) | 2 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 2 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | ||