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. 2023 Oct 27;13:18435. doi: 10.1038/s41598-023-45620-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of six hub genes in TGCTs from the TGCA database. Boxplots of six hub genes expression in TGCTs from TGCA database (A). PRM2, TEKT2, FSCN3, UBQLN3, SPATS1 and GTSF1L were significantly down-regulated in TGCT samples compared to normal controls. *P < 0.05. Methylation levels of 6 hub genes in TGCT and control groups (B). The methylation levels of PRM2, TEKT2, FSCN3, UBQLN3, SPATS1 and GTSF1L were significantly changed in TGCT samples compared to normal controls (P < 0.05). Among them, the methylation levels of PRM2, FSCN3, UBQLN3 and GTSF1L were significantly increased in TGCT compared to normal samples, while the mean methylation levels of TEKT2 and SPATS1 were decreased (P < 0.05). ROC analysis showed six hub genes showed good prognostic value with an area under the curve (AUC) ≥ 0.7 (C). TEKT2 (AUC = 0.954, 95% CI: 0.842–1.000; PRM2 (AUC = 0.880, 95%CI: 0.731–0.981); FSCN3 (AUC = 0.944, 95% CI: 0.815–1.000); UBQLN3(AUC = 0.926, 95% CI: 0.750–1.000); SPATS1(AUC = 0.815, 95% CI: 0.630–0.954); GTSF1L (AUC = 0.861, 95% CI: 0.713–0.963).