Table 1.
Sources of secondary summary statistics used to derive instrumental variables for adult body constitution and hearing loss.
| Phenotypes | Source | Year of publication | Codes*, references or ICD codes | Sample size | Cases (n) | Controls (n) | Cases (%) |
|---|---|---|---|---|---|---|---|
| Body constitution-related phenotypes | |||||||
| Body mass index | UK Biobank | 2018 | 21001 | 359,983 | NA | NA | NA |
| Body mass index | GIANT | 2015 | Locke et al.16 | 322,154 | NA | NA | NA |
| Waist circumference | UK Biobank | 2018 | 48 | 360,564 | NA | NA | NA |
| Waist circumference | GIANT | 2015 | Shungin et al.17 | 210,088 | NA | NA | NA |
| Body fat percentage | UK Biobank | 2018 | 23099 | 354,628 | NA | NA | NA |
| Hearing loss-related phenotypes | |||||||
| Sensorineural hearing loss | FinnGen | Release 6, 2022 | ICD 10: H90.3-5; ICD9: 3891 | 252,719 | 19,313 | 233,406 | 7.64 |
| Noise-induced hearing loss | Finngen | Release 6, 2022 | ICD 10: H83.3; ICD 9: 3881 | 249,936 | 655 | 249,281 | 0.26 |
| Age-related hearing impairment | UK Biobank | 2019 | Wells et al.19 | 250,389 | 87,056 | 163,333 | 34.77 |
GIANT Genetic Investigation of ANthropometric Traits, ICD International Classification of Disease. * UK Biobank phenotype ID codes