Table 2.
Summary data and statistical power calculation for the forward analyses.
| Exposures | Source | Outcomes | Source | Included Variants (n) | Variance explained (%) | Detectable OR* |
|---|---|---|---|---|---|---|
| BMI (kg/m2) | UKB | SNHL | FinnGen | 89 | 1.51 | 1.19 |
| BMI (kg/m2) | UKB | NIHL | FinnGen | 89 | 1.51 | 2.44 |
| BMI (kg/m2) | GIANT | ARHI | UKB | 68 | 2.25 | 1.08 |
| WC (cm) | UKB | SNHL | FinnGen | 72 | 0.83 | 1.26 |
| WC (cm) | UKB | NIHL | FinnGen | 72 | 0.83 | 3.33 |
| WC (cm) | GIANT | ARHI | UKB | 41 | 1.42 | 1.10 |
| BFP (%) | UKB | SNHL | FinnGen | 85 | 0.71 | 1.28 |
| BFP (%) | UKB | NIHL | FinnGen | 85 | 0.71 | 3.67 |
| BFP (%) | UKB | ARHI | UKB | 87 | 0.73 | 1.15 |
*Minimum detectable odds ratio per 1 SD change in the exposure, at 80% power and type 1 error rate=0.05.
BMI body mass index, WC waist circumference, BFP body fat percentage, SNHL sensorineural hearing loss, NIHL noise-induced hearing loss, ARHI age-related hearing impairment, UKB UK Biobank, GIANT Genetic Investigation of ANthropometric Traits.