Table 3.
PRRs and RORs for drugs with NMS reported in JADER.
| Drug | Cases | Non-cases | Total | χ2 | PRR (95% CI) | ROR (95% CI) |
|---|---|---|---|---|---|---|
| Total | 2991 | 1,121,146 | 1,124,137 | |||
| Risperidone | 252 | 2282 | 2534 | 8929.07 | 40.72 (35.57–46.63) | 45.11 (39.40–51.65) |
| Aripiprazole | 220 | 2282 | 2502 | 6838.47 | 35.59 (30.84–41.08) | 38.93 (33.73–44.92) |
| Haloperidol | 206 | 796 | 1002 | 15,486.77 | 82.91 (70.82–97.07) | 104.11 (88.92–121.89) |
| Olanzapine | 151 | 1805 | 1956 | 4074.30 | 30.50 (25.73–36.16) | 32.97 (27.82–39.08) |
| Quetiapine fumarate | 121 | 1716 | 1837 | 2746.43 | 25.76 (21.34–31.08) | 27.50 (22.79–33.19) |
| Blonanserin | 118 | 644 | 762 | 6598.68 | 60.55 (49.59–73.93) | 71.46 (58.53–87.25) |
| Paroxetine hydrochloride hemihydrate | 71 | 2853 | 2924 | 508.31 | 9.32 (7.35–11.83) | 9.53 (7.51–12.10) |
| Levomepromazine maleate | 71 | 575 | 646 | 2761.32 | 42.29 (32.96–54.26) | 47.39 (36.93–60.80) |
| Biperiden hydrochloride | 62 | 435 | 497 | 2747.04 | 47.86 (36.59–62.60) | 54.54 (41.69–71.33) |
| Perospirone hydrochloride hydrate* | 58 | 316 | 374 | 3218.14 | 59.42 (44.80–78.80) | 70.14 (52.89–93.02) |
| Sulpiride | 58 | 929 | 987 | 1150.68 | 22.50 (17.22–29.41) | 23.85 (18.24–31.17) |
| Lithium carbonate | 56 | 806 | 862 | 1238.55 | 24.86 (18.92–32.68) | 26.52 (20.18–34.86) |
| Flunitrazepam | 56 | 980 | 1036 | 1012.83 | 20.68 (15.76–27.14) | 21.81 (16.62–28.62) |
| Amantadine hydrochloride | 53 | 801 | 854 | 1114.09 | 23.73 (17.93–31.41) | 25.23 (19.06–33.40) |
| Paliperidone | 40 | 414 | 454 | 1217.58 | 33.55 (24.20–46.50) | 36.69 (26.47–50.86) |
| Donepezil hydrochloride | 39 | 1720 | 1759 | 245.42 | 8.43 (6.12–11.60) | 8.60 (6.25–11.83) |
| Carbamazepine | 34 | 5083 | 5117 | 29.25 | 2.51 (1.79–3.53) | 2.52 (1.80–3.54) |
| Chlorpromazine hydrochloride | 33 | 292 | 325 | 1160.77 | 38.58 (26.87–55.39) | 42.82 (29.82–61.49) |
| Fluvoxamine maleate | 31 | 837 | 868 | 345.29 | 13.55 (9.45–19.43) | 14.02 (9.78–20.10) |
| Brexpiprazole | 30 | 185 | 215 | 1467.03 | 52.96 (35.95–78.03) | 61.39 (41.67–90.44) |
| Midazolam | 30 | 1073 | 1103 | 241.34 | 10.32 (7.16–14.85) | 10.58 (7.34–15.23) |
| Milnacipran hydrochloride | 30 | 392 | 422 | 719.36 | 26.98 (18.58–39.18) | 28.97 (19.95–42.06) |
| Etizolam | 29 | 964 | 993 | 253.97 | 11.07 (7.64–16.05) | 11.38 (7.85–16.49) |
| Tiapride hydrochloride | 28 | 280 | 308 | 871.20 | 34.48 (23.34–50.94) | 37.83 (25.61–55.88) |
| Promethazine hydrochloride | 27 | 164 | 191 | 1333.13 | 53.60 (35.62–80.66) | 62.26 (41.38–93.70) |
| Zotepine | 27 | 257 | 284 | 879.66 | 36.05 (24.21–53.68) | 39.73 (26.68–59.16) |
| Clozapine | 27 | 2204 | 2231 | 71.57 | 4.58 (3.13–6.71) | 4.62 (3.16–6.77) |
| Paliperidone palmitate | 27 | 643 | 670 | 343.83 | 15.27 (10.38–22.49) | 15.87 (10.78–23.37) |
| Clomipramine hydrochloride | 26 | 222 | 248 | 937.80 | 39.74 (26.43–59.75) | 44.28 (29.45–66.57) |
| Valproate sodium | 26 | 2469 | 2495 | 53.85 | 3.94 (2.67–5.81) | 3.97 (2.70–5.86) |
| Chlorpromazine hydrochloride, promethazine hydrochloride and phenobarbital (1)*,† (Suspension of sale) | 25 | 273 | 298 | 710.91 | 31.79 (21.07–47.95) | 34.61 (22.94–52.21) |
| Asenapine maleate | 25 | 257 | 282 | 753.94 | 33.59 (22.24–50.73) | 36.76 (24.34–55.52) |
| Sertraline hydrochloride | 23 | 1200 | 1223 | 114.26 | 7.12 (4.70–10.77) | 7.23 (4.78–10.94) |
| Amoxapine | 23 | 384 | 407 | 424.86 | 21.40 (14.03–32.64) | 22.62 (14.83–34.50) |
| Levodopa and benserazide hydrochloride | 20 | 234 | 254 | 525.84 | 29.79 (18.84–47.09) | 32.25 (20.40–50.98) |
| Haloperidol decanoate | 20 | 90 | 110 | 1263.99 | 68.79 (42.32–111.82) | 83.85 (51.58–136.31) |
NMS neuroleptic malignant syndrome, PRR proportional reporting ratios, ROR reporting odds ratio.
*Sold only in Japan.
†The numbers are assigned because they were different product names due to differences in standards.