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. 2023 Oct 27;13:18412. doi: 10.1038/s41598-023-44862-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Study design. The exploratory cohort served initially to investigate what symptomatic complaints and exam findings were common to patients presenting with bothersome LUTS who did not exhibit the classic symptoms of overactive bladder (OAB) or interstitial cystitis/bladder pain syndrome (IC/BPS). After identifying that these patients displayed multiple features of myofascial dysfunction, a phenotype we dubbed myofascial urinary frequency syndrome (MUFS), we verified the most salient features of MUFS by comparison of a group of subjects with LUTS, abnormal pelvic floor findings on exam and EMG findings of a tonically contracted pelvic floor to asymptomatic subjects and patients with confirmed OAB and IC/BPS (Reassessment Cohort).