Table 3.

Multivariable-Adjusted Hazard Ratios and 95% Confidence Intervals of Associations with Overall and Cancer-Specific Survival in Adolescents and Young Adults 15–39 Years with Localized Synovial Sarcoma, 2000–2018

	Overall survival		Cancer-specific survival
Characteristics	HR (95% CI)	p	HR (95% CI)	p
Age
15–18	Reference		Reference
19–30	1.45 (0.65–3.24)	0.364	1.59 (0.67–3.82)	0.296
31–39	1.76 (0.78–3.98)	0.175	1.40 (0.56–3.50)	0.472
Sex
Male	Reference		Reference
Female	0.61 (0.36–1.03)	0.065	0.61 (0.34–1.09)	0.097
Health insurance
Private	Reference		Reference
Public/uninsured	1.49 (0.80–2.78)	0.209	1.44 (0.72–2.88)	0.307
Unknown	1.30 (0.27–6.25)	0.747	1.36 (0.26–6.97)	0.716
Race/ethnicity
NH White	Reference		Reference
Not White	0.98 (0.52–1.85)	0.943	1.01 (0.49–2.05)	0.986
Neighborhood socioeconomic status
Low	2.28 (1.09–4.77)	0.028	2.45 (1.04–5.79)	0.042
Medium	1.50 (0.71–3.20)	0.288	1.66 (0.70–3.93)	0.253
High	Reference		Reference
Tumor size
0–5 cm	Reference		Reference
5.1–10 cm	2.01 (1.02–3.95)	0.043	1.28 (0.59–2.77)	0.535
>10 cm	3.55 (1.65–7.65)	0.001	3.19 (1.40–7.26)	0.006
Radiotherapy treatment
Yes	Reference		Reference
No	1.39 (0.77–2.50)	0.272	1.41 (0.74–2.67)	0.298
Chemotherapy treatment
Yes	Reference		Reference
No	0.89 (0.49–1.63)	0.707	0.62 (0.31–1.24)	0.174
Surgery
Yes	Reference		Reference
No	2.07 (0.79–5.44)	0.138	2.09 (0.69–6.36)	0.194
Initial cancer care at an SCC
None	Reference		Reference
All	1.91 (0.84–4.34)	0.124	1.63 (0.60–4.47)	0.338
Some	2.34 (1.17–4.70)	0.017	3.13 (1.39–7.01)	0.006

Bold values are statistically significant.

Included in strata statement: primary site, distance to NCI-COG facility, Charlson score.

HR, hazard ratio; NCI-COG, National Cancer Institute-Children's Oncology Group; NH, non-Hispanic; SCC, Specialized Cancer Center (Children's Oncology Group and/or National Cancer Institute-designated Comprehensive Cancer Center).