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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Nat Rev Genet. 2023 Apr 6;24(9):642–658. doi: 10.1038/s41576-023-00592-y

Fig. 2 |. Thirty years of gene discovery in ALS and FTD.

Fig. 2 |

The first Mendelian gene for amyotrophic lateral sclerosis (ALS) was identified in 1993 (ref. 19), and the first genome-wide association study (GWAS) for ALS was published in 2007 (ref. 103). Further GWAS and gene hunting studies identified several significant loci (P < 5 × 10−8) and genes associated with ALS, frontotemporal dementia (FTD) or ALS/FTD. Summary-level associations were extracted from the EBI-GWAS website102.