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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Nat Rev Genet. 2023 Apr 6;24(9):642–658. doi: 10.1038/s41576-023-00592-y

Fig. 4 |. A model of ALS that integrates genetics, environment and ageing.

Fig. 4 |

Amyotrophic lateral sclerosis (ALS) may occur owing to multiple overlapping factors, including a primary disease-causing mutation, a genetic predisposition that influences disease manifestation, environmental and lifestyle factors, and ageing. Together, they comprise a multifaceted, complex system, in which the integrity of each element is vital to maintain the integrity of the motor neurons.