Figure 1.

The basic viral dynamics model. (A) Cell population processes that are simulated in the mathematical model (Equation (1)). (B,C) Example trajectory of viral load (V) and uninfected target cells (CD4 T cells, T) when $R_0>1$ (red) and $R_0<1$ (blue). Graphs were generated by numerically integrating Equation (1) with parameters $\lambda =100$ cells/µL, $\beta =7\times {10}^{-5}$ or 0/day/(virus/mL), $k=150$ virus/cell, $d_T=0.05/$day, $d_I=0.7/$day, $c=1.7$/day using JSim v2.21 with standard integration parameters [32]. (Figure adapted from Hill [18] and created by part (A) with BioRender.com).