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Positive feedback on the RNAPII pause release rate (PPRR) activation does not influence bimodality of the mRNA and protein distributions in the three-state transcriptional cycling model [109]. Updated three-state promoter system with HIV-1 nucleosome remodeling, RelA recruitment, and Tat-mediated transcript elongation, which is amplified via positive feedback. Positive feedback is modeled as a saturating function with an amplitude, A, and half-max, K.
