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. 2023 Oct 28;22:222. doi: 10.1186/s12934-023-02215-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Transcriptomic and proteomic profiling of the wild type S. rimosus ATCC 10970 (R7), its mutagenized oxytetracycline-producing derivative HP126 (HP), and the chassis strain HP126 ∆v3 (DV3), created by deletion of the oxytetracycline cluster. The data show differences in the expression of genes associated with primary catabolic and anabolic carbon metabolism (A) and secondary metabolism (B). The differences in expression are represented as M-values between strain HP versus R7 (y-axis) and strain DV3 versus wild-type (x-axis) so that correlations between all strains can be inferred from the plot. The data represent the major phase of oxytetracycline production after 24 h. The functional annotation of genes, designated by SRIMR7 numbers on basis of the sequenced genomes, is provided in Additional file 2. Correlation between gene expression and protein abundance in all strains after 24 h (C). The differences between strains are represented as M-values for the proteome (y-axis) and the transcriptome (x-axis). The oxytetracycline cluster genes are shown in orange (HP versus R7) and dark blue (DV3 versus R7). n = 3