Comparison 1. Bendrofluazide versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systolic blood pressure	1	257	Mean Difference (IV, Fixed, 95% CI)	‐10.43 [‐14.06, ‐6.80]
1.1 1.25 mg/day	1	63	Mean Difference (IV, Fixed, 95% CI)	‐7.70 [‐14.98, ‐0.42]
1.2 2.5 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	‐10.9 [‐18.14, ‐3.66]
1.3 5.0 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	‐10.6 [‐17.84, ‐3.36]
1.4 10 mg/day	1	64	Mean Difference (IV, Fixed, 95% CI)	‐12.5 [‐19.76, ‐5.24]
2 Diastolic blood pressure	1	257	Mean Difference (IV, Fixed, 95% CI)	‐6.48 [‐8.82, ‐4.14]
2.1 1.25 mg/day	1	63	Mean Difference (IV, Fixed, 95% CI)	‐5.80 [‐10.49, ‐1.11]
2.2 2.5 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	‐6.9 [‐11.57, ‐2.23]
2.3 5.0 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	‐6.20 [‐10.87, ‐1.53]
2.4 10 mg/day	1	64	Mean Difference (IV, Fixed, 95% CI)	‐7.0 [‐11.68, ‐2.32]
3 Withdrawals due to adverse effects	1	257	Odds Ratio (M‐H, Fixed, 95% CI)	0.19 [0.07, 0.57]
3.1 1.25 mg/day	1	63	Odds Ratio (M‐H, Fixed, 95% CI)	0.23 [0.03, 1.81]
3.2 2.5 mg/day	1	65	Odds Ratio (M‐H, Fixed, 95% CI)	0.22 [0.03, 1.74]
3.3 5.0 mg/day	1	65	Odds Ratio (M‐H, Fixed, 95% CI)	0.11 [0.01, 1.30]
3.4 10 mg/day	1	64	Odds Ratio (M‐H, Fixed, 95% CI)	0.22 [0.03, 1.77]
4 Serum potassium mmol/L	1	257	Mean Difference (IV, Fixed, 95% CI)	‐0.37 [‐0.50, ‐0.24]
4.1 1.25 mg/day	1	63	Mean Difference (IV, Fixed, 95% CI)	‐0.25 [‐0.51, 0.01]
4.2 2.5 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	‐0.29 [‐0.54, ‐0.04]
4.3 5.0 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	‐0.42 [‐0.68, ‐0.16]
4.4 10 mg/day	1	64	Mean Difference (IV, Fixed, 95% CI)	‐0.54 [‐0.80, ‐0.28]
5 Serum uric acid µmol/L	1	257	Mean Difference (IV, Fixed, 95% CI)	46.57 [33.24, 59.91]
5.1 1.25 mg/day	1	63	Mean Difference (IV, Fixed, 95% CI)	24.0 [0.04, 47.96]
5.2 2.5 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	34.0 [8.33, 59.67]
5.3 5.0 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	68.0 [33.12, 102.88]
5.4 10 mg/day	1	64	Mean Difference (IV, Fixed, 95% CI)	73.0 [47.55, 98.45]
6 Serum creatinine µmol/L	1	257	Mean Difference (IV, Fixed, 95% CI)	5.50 [1.90, 9.11]
6.1 1.25 mg/day	1	63	Mean Difference (IV, Fixed, 95% CI)	5.1 [‐1.89, 12.09]
6.2 2.5 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	5.2 [‐1.63, 12.03]
6.3 5.0 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	5.00 [‐3.58, 13.58]
6.4 10 mg/day	1	64	Mean Difference (IV, Fixed, 95% CI)	6.5 [‐0.33, 13.33]
7 Serum blood glucose mmol/L	1	257	Mean Difference (IV, Fixed, 95% CI)	0.13 [‐0.06, 0.33]
7.1 1.25 mg/day	1	63	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.49, 0.27]
7.2 2.5 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	0.22 [‐0.15, 0.59]
7.3 5.0 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	0.12 [‐0.25, 0.49]
7.4 10 mg/day	1	64	Mean Difference (IV, Fixed, 95% CI)	0.35 [‐0.09, 0.79]
8 Total cholesterol mmol/L	1	257	Mean Difference (IV, Fixed, 95% CI)	0.15 [‐0.05, 0.35]
8.1 1.25 mg/day	1	63	Mean Difference (IV, Fixed, 95% CI)	0.03 [‐0.38, 0.44]
8.2 2.5 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	0.06 [‐0.34, 0.46]
8.3 5.0 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	0.18 [‐0.22, 0.58]
8.4 10 mg/day	1	64	Mean Difference (IV, Fixed, 95% CI)	0.31 [‐0.08, 0.70]
9 Triglycerides mmol/L	1	257	Mean Difference (IV, Fixed, 95% CI)	0.26 [‐0.06, 0.58]
9.1 1.25 mg/day	1	63	Mean Difference (IV, Fixed, 95% CI)	0.13 [‐0.49, 0.75]
9.2 2.5 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	0.52 [‐0.11, 1.15]
9.3 5.0 mg/day	1	65	Mean Difference (IV, Fixed, 95% CI)	0.08 [‐0.65, 0.81]
9.4 10 mg/day	1	64	Mean Difference (IV, Fixed, 95% CI)	0.27 [‐0.34, 0.88]