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. 2014 May 29;2014(5):CD003824. doi: 10.1002/14651858.CD003824.pub2

Comparison 2. Cyclopenthiazide versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Systolic blood pressure 1 53 Mean Difference (IV, Fixed, 95% CI) ‐10.75 [‐18.44, ‐3.05]
1.1 0.05 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) ‐5.3 [‐18.71, 8.11]
1.2 0.125 mg/day 1 19 Mean Difference (IV, Fixed, 95% CI) ‐12.0 [‐25.16, 1.16]
1.3 0.5 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) ‐14.90 [‐28.31, ‐1.49]
2 Diastolic blood pressure 1 53 Mean Difference (IV, Fixed, 95% CI) ‐6.23 [‐11.19, ‐1.27]
2.1 0.05 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) ‐3.0 [‐11.65, 5.65]
2.2 0.125mg/day 1 19 Mean Difference (IV, Fixed, 95% CI) ‐8.60 [‐17.09, ‐0.11]
2.3 0.5 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) ‐7.0 [‐15.65, 1.65]
3 Serum potassium µmol/L 1 53 Mean Difference (IV, Fixed, 95% CI) ‐0.18 [‐0.42, 0.07]
3.1 0.05 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) 0.10 [‐0.35, 0.55]
3.2 0.125 mg/day 1 19 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.52, 0.32]
3.3 0.5 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) ‐0.50 [‐0.92, ‐0.08]
4 Serum uric acid µmol/L 1 53 Mean Difference (IV, Fixed, 95% CI) 19.54 [‐36.18, 75.26]
4.1 0.05 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) 30.0 [‐70.86, 130.86]
4.2 0.125 mg/day 1 19 Mean Difference (IV, Fixed, 95% CI) 20.0 [‐75.05, 115.05]
4.3 0.5 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) 10.0 [‐84.04, 104.04]
5 Total cholesterol mmol/L 1 47 Mean Difference (IV, Fixed, 95% CI) 0.79 [0.36, 1.23]
5.1 0.05 mg/day 1 16 Mean Difference (IV, Fixed, 95% CI) 1.2 [0.46, 1.94]
5.2 0.125 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) 0.90 [0.17, 1.63]
5.3 0.5 mg/day 1 14 Mean Difference (IV, Fixed, 95% CI) 0.2 [‐0.60, 1.00]
6 Triglycerides mmol/L 1 48 Mean Difference (IV, Fixed, 95% CI) 0.20 [‐0.17, 0.57]
6.1 0.05 mg/day 1 16 Mean Difference (IV, Fixed, 95% CI) 0.3 [‐0.30, 0.90]
6.2 0.125 mg/day 1 17 Mean Difference (IV, Fixed, 95% CI) 0.4 [‐0.29, 1.09]
6.3 0.5 mg/day 1 15 Mean Difference (IV, Fixed, 95% CI) ‐0.1 [‐0.74, 0.54]