Comparison 3. Metolazone versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systolic blood pressure	1	105	Mean Difference (IV, Fixed, 95% CI)	‐11.63 [‐16.89, ‐6.38]
1.1 0.5 mg/day	1	35	Mean Difference (IV, Fixed, 95% CI)	‐11.40 [‐20.50, ‐2.30]
1.2 1.0 mg/day	1	34	Mean Difference (IV, Fixed, 95% CI)	‐11.6 [‐20.75, ‐2.45]
1.3 2 mg/day	1	36	Mean Difference (IV, Fixed, 95% CI)	‐11.90 [‐20.95, ‐2.85]
2 Diastolic blood pressure	1	105	Mean Difference (IV, Fixed, 95% CI)	‐5.83 [‐9.22, ‐2.44]
2.1 0.5 mg/day	1	35	Mean Difference (IV, Fixed, 95% CI)	‐5.90 [‐11.77, ‐0.03]
2.2 1.0 mg/day	1	34	Mean Difference (IV, Fixed, 95% CI)	‐6.40 [‐12.30, ‐0.50]
2.3 2.0 mg/day	1	36	Mean Difference (IV, Fixed, 95% CI)	‐5.2 [‐11.04, 0.64]