Comparison 4. Chlorthalidone versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systolic blood pressure	7	1153	Mean Difference (IV, Fixed, 95% CI)	‐11.98 [‐13.71, ‐10.24]
1.1 12.5 to 15 mg/day	3	185	Mean Difference (IV, Fixed, 95% CI)	‐10.09 [‐13.88, ‐6.30]
1.2 25 to 30 mg/day	5	752	Mean Difference (IV, Fixed, 95% CI)	‐13.64 [‐16.03, ‐11.25]
1.3 45 to 50 mg/day	4	192	Mean Difference (IV, Fixed, 95% CI)	‐9.92 [‐13.44, ‐6.39]
1.4 75 mg/day	1	24	Mean Difference (IV, Fixed, 95% CI)	‐12.9 [‐24.65, ‐1.15]
2 Diastolic blood pressure	7	1153	Mean Difference (IV, Fixed, 95% CI)	‐3.93 [‐5.13, ‐2.74]
2.1 12.5 to 15 mg/day	3	185	Mean Difference (IV, Fixed, 95% CI)	‐2.55 [‐5.07, ‐0.02]
2.2 25 to 30 mg/day	5	752	Mean Difference (IV, Fixed, 95% CI)	‐3.98 [‐5.69, ‐2.28]
2.3 45 to 50 mg/day	4	192	Mean Difference (IV, Fixed, 95% CI)	‐4.91 [‐7.29, ‐2.53]
2.4 75 mg/day	1	24	Mean Difference (IV, Fixed, 95% CI)	‐5.5 [‐13.08, 2.08]
3 Withdrawals due to adverse events	5	1058	Odds Ratio (M‐H, Fixed, 95% CI)	0.49 [0.28, 0.87]
3.1 12.5 mg/day	2	85	Odds Ratio (M‐H, Fixed, 95% CI)	0.11 [0.02, 0.55]
3.2 15 mg/day	1	101	Odds Ratio (M‐H, Fixed, 95% CI)	0.79 [0.13, 4.94]
3.3 25 mg/day	4	732	Odds Ratio (M‐H, Fixed, 95% CI)	0.68 [0.29, 1.57]
3.4 45 mg/day	1	34	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.5 50 mg/day	2	81	Odds Ratio (M‐H, Fixed, 95% CI)	0.42 [0.13, 1.43]
3.6 75 mg/day	1	25	Odds Ratio (M‐H, Fixed, 95% CI)	0.85 [0.03, 23.82]
4 Serum potassium mmol/L	5	1203	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.45, ‐0.34]
4.1 12.5 to 15 mg/day	3	235	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.51, ‐0.29]
4.2 25 to 30 mg/day	4	784	Mean Difference (IV, Fixed, 95% CI)	‐0.26 [‐0.34, ‐0.19]
4.3 50 mg/day	3	161	Mean Difference (IV, Fixed, 95% CI)	‐0.77 [‐0.90, ‐0.64]
4.4 75 mg/day	1	23	Mean Difference (IV, Fixed, 95% CI)	‐0.6 [‐1.05, ‐0.15]
5 Serum uric acid µmol/L	2	285	Mean Difference (IV, Fixed, 95% CI)	64.16 [45.69, 82.63]
5.1 12.5 to 15 mg/day	2	120	Mean Difference (IV, Fixed, 95% CI)	52.71 [26.11, 79.30]
5.2 25 to 30 mg/day	2	120	Mean Difference (IV, Fixed, 95% CI)	74.44 [47.85, 101.02]
5.3 50 mg/day	1	22	Mean Difference (IV, Fixed, 95% CI)	90.0 [‐47.99, 227.99]
5.4 75 mg/day	1	23	Mean Difference (IV, Fixed, 95% CI)	70.0 [‐70.76, 210.76]
6 Serum blood glucose mmol/L	3	394	Mean Difference (IV, Fixed, 95% CI)	0.34 [0.12, 0.55]
6.1 12.5 mg/day	1	24	Mean Difference (IV, Fixed, 95% CI)	0.17 [‐0.68, 1.02]
6.2 15 mg/day	1	122	Mean Difference (IV, Fixed, 95% CI)	0.05 [‐0.33, 0.43]
6.3 25 to 30 mg/day	2	147	Mean Difference (IV, Fixed, 95% CI)	0.58 [0.23, 0.93]
6.4 50 mg/day	2	77	Mean Difference (IV, Fixed, 95% CI)	0.43 [‐0.04, 0.91]
6.5 75 mg/day	1	24	Mean Difference (IV, Fixed, 95% CI)	0.17 [‐0.61, 0.95]
7 HDL cholesterol mmol/L	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
7.1 45 mg/day	1	34	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.22, 0.00]
8 Total cholesterol mmol/L	2	213	Mean Difference (IV, Fixed, 95% CI)	0.41 [0.18, 0.64]
8.1 15 mg/day	1	88	Mean Difference (IV, Fixed, 95% CI)	0.23 [‐0.24, 0.70]
8.2 25 mg/day	1	91	Mean Difference (IV, Fixed, 95% CI)	0.20 [‐0.24, 0.64]
8.3 45 mg/day	1	34	Mean Difference (IV, Fixed, 95% CI)	0.6 [0.28, 0.92]
9 Triglycerides mmol/L	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
9.1 45 mg/day	1	34	Mean Difference (IV, Fixed, 95% CI)	0.69 [0.05, 1.33]