Comparison 6. Indapamide versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systolic blood pressure	10	2104	Mean Difference (IV, Fixed, 95% CI)	‐8.69 [‐9.96, ‐7.42]
1.1 1.0 mg/day	1	29	Mean Difference (IV, Fixed, 95% CI)	‐9.7 [‐19.89, 0.49]
1.2 1.25 mg/day	4	736	Mean Difference (IV, Fixed, 95% CI)	‐7.37 [‐9.21, ‐5.54]
1.3 1.5 mg/day	2	955	Mean Difference (IV, Fixed, 95% CI)	‐9.40 [‐11.51, ‐7.29]
1.4 2.0 mg/day	1	74	Mean Difference (IV, Fixed, 95% CI)	‐8.7 [‐17.38, ‐0.02]
1.5 2.5 mg/day	5	281	Mean Difference (IV, Fixed, 95% CI)	‐11.94 [‐15.88, ‐7.99]
1.6 5.0 mg/day	1	29	Mean Difference (IV, Fixed, 95% CI)	‐9.6 [‐19.40, 0.20]
2 Diastolic blood pressure	10	2104	Mean Difference (IV, Fixed, 95% CI)	‐3.88 [‐4.63, ‐3.14]
2.1 1.0 mg/day	1	29	Mean Difference (IV, Fixed, 95% CI)	‐1.00 [‐9.57, 3.57]
2.2 1.25 mg/day	4	736	Mean Difference (IV, Fixed, 95% CI)	‐3.55 [‐4.57, ‐2.52]
2.3 1.5 mg/day	2	955	Mean Difference (IV, Fixed, 95% CI)	‐4.05 [‐5.38, ‐2.72]
2.4 2.0 mg/day	1	74	Mean Difference (IV, Fixed, 95% CI)	‐3.60 [‐8.27, 1.07]
2.5 2.5 mg/day	5	281	Mean Difference (IV, Fixed, 95% CI)	‐5.32 [‐7.65, ‐2.98]
2.6 5.0 mg/day	1	29	Mean Difference (IV, Fixed, 95% CI)	‐4.0 [‐10.32, 2.32]
3 Withdrawals due to adverse events	6	1874	Odds Ratio (M‐H, Fixed, 95% CI)	0.83 [0.49, 1.42]
3.1 1.0 mg/day	1	29	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.00, 2.66]
3.2 1.25 mg/day	3	621	Odds Ratio (M‐H, Fixed, 95% CI)	1.07 [0.49, 2.32]
3.3 1.5 mg/day	2	958	Odds Ratio (M‐H, Fixed, 95% CI)	0.73 [0.30, 1.79]
3.4 2.0 mg/day	1	74	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.02, 5.61]
3.5 2.5 mg/day	2	163	Odds Ratio (M‐H, Fixed, 95% CI)	1.06 [0.17, 6.53]
3.6 5.0 mg/day	1	29	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Serum potassium mmol/L	5	541	Mean Difference (IV, Fixed, 95% CI)	‐0.32 [‐0.38, ‐0.26]
4.1 1.0 mg/day	1	31	Mean Difference (IV, Fixed, 95% CI)	‐0.11 [‐0.38, 0.16]
4.2 1.25 mg/day	2	398	Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐0.37, ‐0.23]
4.3 2.5 mg/day	3	81	Mean Difference (IV, Fixed, 95% CI)	‐0.41 [‐0.57, ‐0.26]
4.4 5.0 mg/day	1	31	Mean Difference (IV, Fixed, 95% CI)	‐0.65 [‐0.91, ‐0.39]
5 Serum uric acid µmol/L	4	558	Mean Difference (IV, Fixed, 95% CI)	39.81 [33.54, 46.08]
5.1 1.0 mg/day	1	46	Mean Difference (IV, Fixed, 95% CI)	35.69 [14.15, 57.23]
5.2 1.25 mg/day	2	398	Mean Difference (IV, Fixed, 95% CI)	36.14 [28.70, 43.58]
5.3 2.5 mg/day	2	69	Mean Difference (IV, Fixed, 95% CI)	52.33 [34.50, 70.16]
5.4 5.0 mg/day	1	45	Mean Difference (IV, Fixed, 95% CI)	57.17 [35.17, 79.17]
6 Serum creatinine µmol/L	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
6.1 1.25 mg/day	1	203	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐2.43, 2.43]
7 Serum blood glucose mmol/L	3	490	Mean Difference (IV, Fixed, 95% CI)	0.13 [‐0.11, 0.37]
7.1 1.0 mg/day	1	31	Mean Difference (IV, Fixed, 95% CI)	‐0.08 [‐1.12, 0.96]
7.2 1.25 mg/day	2	398	Mean Difference (IV, Fixed, 95% CI)	0.12 [‐0.14, 0.38]
7.3 2.5 mg/day	1	30	Mean Difference (IV, Fixed, 95% CI)	0.34 [‐0.71, 1.39]
7.4 5.0 mg/day	1	31	Mean Difference (IV, Fixed, 95% CI)	0.25 [‐0.76, 1.26]
8 HDL cholesterol mmol/L	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
8.1 1.25 mg/day	1	203	Mean Difference (IV, Fixed, 95% CI)	‐0.05 [‐0.10, ‐0.00]
9 Total cholesterol mmol/L	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
9.1 1.25 mg/day	2	398	Mean Difference (IV, Fixed, 95% CI)	0.12 [0.02, 0.23]
10 Triglycerides mmol/L	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
10.1 1.25 mg/day	1	203	Mean Difference (IV, Fixed, 95% CI)	0.23 [0.03, 0.43]