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. 2014 May 29;2014(5):CD003824. doi: 10.1002/14651858.CD003824.pub2

Comparison 7. Thiazide versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Systolic blood pressure 47 7733 Mean Difference (IV, Fixed, 95% CI) ‐9.14 [‐9.76, ‐8.51]
1.1 Bendrofluazide 1.25 to 10 mg/day 1 257 Mean Difference (IV, Fixed, 95% CI) ‐10.4 [‐14.03, ‐6.77]
1.2 Chlorthalidone 12.5 to 100 mg/day 7 1167 Mean Difference (IV, Fixed, 95% CI) ‐11.79 [‐13.50, ‐10.08]
1.3 Cyclopenthiazide 0.5 mg/day 1 25 Mean Difference (IV, Fixed, 95% CI) ‐14.90 [‐24.58, ‐5.22]
1.4 Hydrochlorothiazide 25 to 100 mg/day 28 4099 Mean Difference (IV, Fixed, 95% CI) ‐8.68 [‐9.49, ‐7.87]
1.5 Indapamide 1.0 to 5.0 mg/day 9 2080 Mean Difference (IV, Fixed, 95% CI) ‐8.37 [‐9.65, ‐7.10]
1.6 Metolazone 0.5 to 2.0 mg/day 1 105 Mean Difference (IV, Fixed, 95% CI) ‐11.7 [‐16.95, ‐6.45]
2 Diastolic blood pressure 51 8064 Mean Difference (IV, Fixed, 95% CI) ‐3.63 [‐3.97, ‐3.28]
2.1 Bendrofluazide 1.25 to 10 mg/day 1 257 Mean Difference (IV, Fixed, 95% CI) ‐6.5 [‐8.84, ‐4.16]
2.2 Chlorthalidone 12.5 to 100 mg/day 7 1153 Mean Difference (IV, Fixed, 95% CI) ‐3.07 [‐4.27, ‐1.87]
2.3 Cyclopenthiazide 0.125 to 0.5 mg/day 1 40 Mean Difference (IV, Fixed, 95% CI) ‐7.90 [‐13.16, ‐2.64]
2.4 Hydrochlorothiazide 25 to 100 mg/day 32 4429 Mean Difference (IV, Fixed, 95% CI) ‐3.50 [‐3.92, ‐3.08]
2.5 Indapamide 1.0 to 5.0 mg/day 9 2080 Mean Difference (IV, Fixed, 95% CI) ‐3.77 [‐4.52, ‐3.02]
2.6 Metolazone 0.5 to 2.0 mg/day 1 105 Mean Difference (IV, Fixed, 95% CI) ‐5.8 [‐9.19, ‐2.41]
3 Serum potassium mmol/L 22 3868 Mean Difference (IV, Fixed, 95% CI) ‐0.25 [‐0.28, ‐0.22]
3.1 BDFZ 1.25 to 10 mg/day 1 218 Mean Difference (IV, Fixed, 95% CI) ‐0.38 [‐0.62, ‐0.14]
3.2 CTD 12.5 to 100 mg/day 4 1068 Mean Difference (IV, Fixed, 95% CI) ‐0.32 [‐0.38, ‐0.25]
3.3 CYPTZ 0.05 to 0.5 mg/day 1 53 Mean Difference (IV, Fixed, 95% CI) ‐0.20 [‐0.45, 0.05]
3.4 HCTZ 3 to 100 mg/day 11 1988 Mean Difference (IV, Fixed, 95% CI) ‐0.21 [‐0.24, ‐0.17]
3.5 IND 1.0 to 5 mg/day 5 541 Mean Difference (IV, Fixed, 95% CI) ‐0.32 [‐0.38, ‐0.26]
4 Serum uric acid µmol/L 13 2332 Mean Difference (IV, Fixed, 95% CI) 38.22 [34.24, 42.20]
4.1 BDFZ 1.25 to 10 mg/day 1 255 Mean Difference (IV, Fixed, 95% CI) 50.30 [36.62, 63.98]
4.2 CTD 12.5 to 100 mg/day 2 285 Mean Difference (IV, Fixed, 95% CI) 64.74 [46.11, 83.36]
4.3 CYPTZ 0.05 to 0.5 mg/day 1 53 Mean Difference (IV, Fixed, 95% CI) 20.0 [‐35.61, 75.61]
4.4 HCTZ 3 to 100 mg/day 5 1122 Mean Difference (IV, Fixed, 95% CI) 32.74 [26.00, 39.48]
4.5 IND 1.0 to 5 mg/day 4 617 Mean Difference (IV, Fixed, 95% CI) 37.77 [32.23, 43.31]
5 Serum creatinine µmol/L 5 987 Mean Difference (IV, Fixed, 95% CI) 1.34 [‐0.31, 2.99]
5.1 BDFZ 1.25 to 10 mg/day 1 257 Mean Difference (IV, Fixed, 95% CI) 5.45 [1.99, 8.91]
5.2 HCTZ 3 to 100 mg/day 3 527 Mean Difference (IV, Fixed, 95% CI) 0.32 [‐2.63, 3.26]
5.3 IND 1.0 to 5 mg/day 1 203 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐2.43, 2.43]
6 Serum blood glucose mmol/L 12 1989 Mean Difference (IV, Fixed, 95% CI) 0.03 [‐0.05, 0.12]
6.1 BDFZ 1.25 to 10 mg/day 1 257 Mean Difference (IV, Fixed, 95% CI) 0.15 [‐0.04, 0.34]
6.2 CTD 12.5 to 100 mg/day 3 326 Mean Difference (IV, Fixed, 95% CI) 0.37 [0.14, 0.60]
6.3 HCTZ 3 to 100 mg/day 6 916 Mean Difference (IV, Fixed, 95% CI) ‐0.11 [‐0.22, 0.01]
6.4 IND 1.0 to 5 mg/day 3 490 Mean Difference (IV, Fixed, 95% CI) 0.13 [‐0.11, 0.37]
7 Serum total cholesterol mmol/L 11 1394 Mean Difference (IV, Fixed, 95% CI) 0.21 [0.18, 0.23]
7.1 BDFZ 1.25 to 10 mg/day 1 257 Mean Difference (IV, Fixed, 95% CI) 0.44 [0.24, 0.64]
7.2 CTD 12.5 to 100 mg/day 2 213 Mean Difference (IV, Fixed, 95% CI) 0.41 [0.18, 0.63]
7.3 CYPTZ 0.05 to 0.5 mg/day 1 53 Mean Difference (IV, Fixed, 95% CI) 0.79 [0.37, 1.21]
7.4 HCTZ 3 to 100 mg/day 4 450 Mean Difference (IV, Fixed, 95% CI) 0.20 [0.18, 0.23]
7.5 IND 1.0 to 5 mg/day 3 421 Mean Difference (IV, Fixed, 95% CI) 0.11 [0.01, 0.21]
8 Serum HDL mmol/L 3 348 Mean Difference (IV, Fixed, 95% CI) ‐0.06 [‐0.10, ‐0.02]
8.1 CTD 45 mg/day 1 34 Mean Difference (IV, Fixed, 95% CI) ‐0.11 [‐0.22, 0.00]
8.2 HCTZ 25mg/day 1 111 Mean Difference (IV, Fixed, 95% CI) ‐0.15 [‐0.72, 0.42]
8.3 IND 1.25 mg/day 1 203 Mean Difference (IV, Fixed, 95% CI) ‐0.05 [‐0.10, ‐0.00]
9 Triglycerides 6 697 Mean Difference (IV, Fixed, 95% CI) 0.21 [0.08, 0.33]
9.1 BDFZ 1.25 to 10 mg/day 1 157 Mean Difference (IV, Fixed, 95% CI) 0.37 [‐0.09, 0.83]
9.2 CTD 45 mg/day 1 34 Mean Difference (IV, Fixed, 95% CI) 0.69 [0.05, 1.33]
9.3 CYPTZ 0.5 mg/day 1 48 Mean Difference (IV, Fixed, 95% CI) 0.21 [‐0.16, 0.58]
9.4 HCTZ 25 mg/day 2 255 Mean Difference (IV, Fixed, 95% CI) 0.09 [‐0.11, 0.30]
9.5 IND 1.25 mg/day 1 203 Mean Difference (IV, Fixed, 95% CI) 0.23 [0.03, 0.43]