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. 2014 May 29;2014(5):CD003824. doi: 10.1002/14651858.CD003824.pub2
Hydrochlorothiazide Systolic blood pressure mmHg
(95% CI)
Diastolic blood pressure mmHg
(95% CI)
3 to 6.25 mg/day ‐3.6 (‐5.6 to ‐1.5) ‐2.4 (‐3.7 to ‐1.2)
12.5 mg/day ‐6.3 (‐7.2 to ‐5.3) ‐3.1 (‐3.7 to ‐2.5)
25 mg/day ‐8.0 (‐9.0 to ‐7.0) ‐3.3 (‐3.8 to ‐2.8)
37.5 mg/day ‐7.3 (‐16.3 to 1.7) ‐3.7 (‐9.3 to 1.9)
50 mg/day ‐10.5 (‐14.6 to ‐6.4) ‐5.0 (‐6.7 to ‐3.3)
100 mg/day ‐9.9 (‐14.1 to ‐5.8) ‐3.9 (‐6.6 to ‐1.2)
Overall ‐6.9 (‐7.6 to ‐6.3) ‐3.3 (‐3.6 to ‐2.9)