|
Hydrochlorothiazide dose mg/day |
This review Monotherapy versus placebo |
Chen 2009
review Second‐line drug versus placebo |
Weighted combined systolic blood pressure‐lowering effect from both reviews |
||||
| RCTs | # of patients | MD (95% CI) mmHg | RCTs | # of patients | MD (95% CI) mmHg | mmHg | |
| 3.0 to 6.25 | 8 | 663 | ‐3.6 (‐5.6 to ‐1.5) | 22 | 3283 | ‐3.7 (‐4.6 to ‐2.8) | 3.7 |
| 12.5 | 22 | 2645 | ‐6.3 (‐7.2 to ‐5.3) | 53 | 8482 | ‐6.0 (‐6.5 to ‐5.4) | 6.1 |
| 25 | 25 | 3062 | ‐8.0 (‐9.0 to ‐7.0) | 39 | 5799 | ‐8.0 (‐8.7 to ‐7.3) | 8.0 |
| 50 | 2 | 169 | ‐10.5 (‐14.6 to ‐6.4) | 3 | 189 | ‐17.8 (‐21.6 to ‐14.0) | 14.4 |
| 100 | 2 | 146 | ‐9.9 (‐14.1 to ‐5.8) | No data | 9.9 | ||
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