Table 2.

Hazard Ratios (HRs) for Mobility Limitation Per Doubling in Concentration for GDF-11, GDF-8, Follistatin, or Follistatin-Like Protein-3, Health ABC, adjusted for age, sex, and race; and the Multivariable Adjusted as Noted

	HR (95% CI) Per Doubling Concentration of Protein
Log GDF-11	Model 1	Model 2
Persistent severe mobility limitation	0.89 (0.58, 1.39)	0.84 (0.43, 1.64)
Persistent mobility limitation	1.01 (0.75, 1.37)	1.04 (0.66, 1.62)
Log GDF-8
Persistent severe mobility limitation	0.79 (0.63, 0.98)	0.67 (0.48, 0.94)
Persistent mobility limitation	0.97 (0.82, 1.15)	1.02 (0.79, 1.30)
Log Follistatin
Persistent severe mobility limitation	1.20 (0.99, 1.47)	1.13 (0.83, 1.55)
Persistent mobility limitation	1.27 (1.10, 1.46)	1.26 (1.01, 1.56)
Log FSTL-3
Persistent severe mobility limitation	2.47 (1.92, 3.17)	2.41 (1.44, 4.02)
Persistent mobility limitation	2.13 (1.76, 2.57)	1.77 (1.11, 2.56)

Notes: Model 1 is adjusted for age, sex, race; Model 2 is adjusted for covariates in Model 1 and self-rated health, body mass index, cancer, chronic obstructive pulmonary disease, angina, smoking status, drinking status, coronary heart disease, heart failure, cystatin C, C-reactive protein and estimated glomerular filtration rate. FSTL-3 = follistatin-like protein-3; GDF = growth differentiation factor; Health ABC = Health, Aging, and Body Composition study.