Table 2.
Laboratory analyses during index hospitalization.
| All patients N = 538 | Controls N = 416 | Cases N = 122 | Difference (95% CI) | p value | |
|---|---|---|---|---|---|
| Timepoint 1a | |||||
| Leucocytes (G/L) | n = 525, 9.6 ± 4.7 | n = 405, 9.6 ± 4.2 | n = 120, 9.5 ± 6.1 | 0.1 (−0.8; 1.1) | 0.77 |
| Hemoglobin (g/L) | n = 525, 132.6 ± 23.1 | n = 405, 133.8 ± 22.5 | n = 120, 128.7 ± 24.7 | 5.1 (0.4; 9.8) | 0.03 |
| Platelets (G/L) | n = 524, 226.7 ± 78.5 | n = 405, 229.7 ± 78.5 | n = 119, 216.4 ± 78.1 | 13.2 (−2.8; 29.3) | 0.11 |
| hs-CRP (mg/L) | n = 373, 44.1 ± 71.3 | n = 276, 26.7 ± 54.0 | n = 97, 93.5 ± 89.3 | −66.8 (−81.9; −51.8) | <0.001 |
| CK (U/L) | n = 499, 377.7 ± 834.6 | n = 397, 410.1 ± 905.9 | n = 102, 251.3 ± 443.5 | 158.8 (−22.9; 340.4) | 0.09 |
| CKMB (μg/L) | n = 205, 65.5 ± 112.9 | n = 142, 64.5 ± 104.2 | n = 63, 67.6 ± 131.3 | −3.1 (−36.7; 30.6) | 0.86 |
| hs-TnT (ng/L) | n = 500, 774.2 ± 2,556.7 | n = 394, 859.1 ± 2,697.2 | n = 106, 458.7 ± 1,925.8 | 400.4 (−148.5; 949.4) | 0.15 |
| Excluding patients with ACS | n = 252, 178.7 ± 1,163.3 | n = 178, 211.9 ± 1,380.1 | n = 74, 98.8 ± 160.4 | 113.1 (−203.3; 429.5) | 0.48 |
| eGFR (ml/min) | n = 513, 68.2 ± 25.8 | n = 404, 69.3 ± 24.8 | n = 109, 64.2 ± 29.1 | 5.1 (−0.4; 10.5) | 0.07 |
| Timepoint 2b | |||||
| Leucocytes (G/L) | n = 446, 8.5 ± 3.7 | n = 335, 8.2 ± 2.9 | n = 111, 9.2 ± 5.3 | −1.0 (−1.8; −0.2) | 0.01 |
| Hemoglobin (g/L) | n = 447, 120.2 ± 23.3 | n = 335, 122.5 ± 22.3 | n = 112, 113.3 ± 25.0 | 9.2 (4.2; 14.1) | <0.001 |
| Platelets (G/L) | n = 444, 229.3 ± 101.4 | n = 334, 221.4 ± 99.1 | n = 110, 253.2 ± 104.9 | −31.8 (−53.5; −10.1) | 0.004 |
| hs-CRP (mg/L) | n = 244, 38.9 ± 56.6 | n = 159, 29.5 ± 37.5 | n = 85, 56.3 ± 78.4 | −26.7 (−41.3; −12.1) | <0.001 |
| CK (U/L) | n = 416, 710.9 ± 2,110.6 | n = 340, 672.1 ± 1,220.9 | n = 76, 884.5 ± 4,227.6 | −212.4 (−738.7; 313.8) | 0.43 |
| CKMB (μg/L) | n = 241, 56.4 ± 107.2 | n = 178, 63.4 ± 114.7 | n = 63, 36.6 ± 80.0 | 26.8 (−3.9; 57.5) | 0.09 |
| hs-TnT (ng/L) | n = 418, 1,443.9 ± 3,301.8 | n = 338, 1,647.2 ± 3,512.4 | n = 80, 585.1 ± 1,998.3 | 1,062.1 (261.2; 1,863.0) | 0.01 |
| Excluding patients with ACS | n = 196, 142.3 ± 324.7 | n = 138, 144.7 ± 362.9 | n = 58, 136.8 ± 209.9 | 7.8 (−92.3; 107.9) | 0.88 |
| eGFR (ml/min) | n = 473, 66.9 ± 27.6 | n = 377, 67.8 ± 26.5 | n = 96, 63.7 ± 31.7 | 4.0 (−2.2; 10.2) | 0.20 |
CK, creatine kinase; eGFR, estimated glomerular filtration rate; hs-CRP, high-sensitivity C-reactive protein; hs-TnT, high-sensitivity troponin T.
a
Time point closest to admission for index hospitalization.
b
Time point closest to hospital discharge.