This study critically appraises the available literature on topical treatments of psoriasis to specifically address some relevant issues, namely the vehicle associated with the highest effectiveness, the best vehicle for improving adherence, and the best strategy in terms of efficacy and safety for long-term treatment.

The greater effectiveness of the foam formulation was demonstrated for calcipotriene/betamethasone dipropionate administration compared with the gel and ointment.

Literature evidence and clinical experience reported high rates of acceptability and adherence for the foam vehicle.

A growing consensus is shared among dermatologists sustaining the proactive approach as the best option for the long-term topical treatment of psoriasis in adults.