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. 2023 Oct 28;14:6872. doi: 10.1038/s41467-023-42215-4

Fig. 4. Inhibiting tuft cell-driven IL25 signaling inhibits the formation and growth of gastric tumor organoids.

Fig. 4

a Representative images and quantification of relative organoid diameter of 10-day-old organoids derived from gp130F/F tumors and treated with either PBS (vehicle), IgG, IL13, IL25, or α-IL25 at 20 ng/ml for 7 days. Scale bar = 300 μm. Organoid n = 217 (vehicle), 325 (IL13), 322 (IL25), 293 (IgG) and 241 (α-IL25). Created with BioRender.com. Data represents mean ± SEM, p values from two-sided Student’s t-test *p < 0.05, ****p < 0.0001. Data is from two pooled experiments, each comprising 4 domes of organoids per group. Source data and exact p values are provided as a Source Data file.