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. 2023 Oct 12;14:1169292. doi: 10.3389/fphar.2023.1169292

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Copyright © 2023 Wang, Chen, Wei, Ding, Guo, Xing and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Data analysis of clinical efficacy rates (XYS combined with anxiolytics vs. anxiolytics alone). (A) Meta-analysis. (B) Trial sequential analysis. The blue line represents the cumulative number of cases in the meta-analysis, also called the “Z-curve”. The horizontal straight red line shows the conventional test boundary, which is a traditional significant horizontal line (α = 0.05). The twisted red line represents the trial sequential monitoring boundary, which is an interface curve formed by correcting the random error generated by the meta-analysis. The vertical, straight red line represents the required information size (RIS) and refers to the number of cases required for meta-analysis to obtain statistically significant differences. The cumulative Z-curve surpassed the point of no return and increased to the necessary information size.