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. 2023 Oct 29;13:18558. doi: 10.1038/s41598-023-45903-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier analysis of the relationship between S_Ox and new-onset cardiovascular disease events. Subjects were divided into two groups by median S_Ox concentration (S_Ox < 266.9 µmol/L and S_Ox ≥ 266.9 µmol/L). New-onset cardiovascular events occurred in 29/60 (48.3%) patients: in 19/30 (63.3%) patients with S_Ox greater than or equal to the median value and in 10/30 (33.3%) patients with S_Ox less than the median value. The number of events was significantly higher in the patients with S_Ox ≥ 266.9 µmol/L than in those with S_Ox < 266.9 µmol/L (a), even after limiting the analysis only to patients with CAC score < 1000 and without history of cardiovascular disease (n = 33, b). CAC coronary artery calcification, CI confidence interval, HR hazard ratio, S_Ox serum oxalate.