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. 2023 Oct 29;13:18554. doi: 10.1038/s41598-023-45721-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Synergistic proapoptotic effects of INCB057643 combined with selinexor in HGBCL-DH cells with TP53 mutations. (A,B) INCB057643 synergized with selinexor to promote apoptosis in VAL (A) and TMD8 (B) cells. The left panel shows the specific apoptosis rates, and the right panel shows the CI values. (C) Analysis of the therapeutic interaction of selinexor and INCB057643 in inducing apoptosis in Toledo cells. The top and bottom panels show the specific apoptosis rates and CI values, respectively. (D) Representative flow plots of VAL, TMD8 and Toledo cells treated as described in (A–C).