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. 2023 Oct 29;13:18554. doi: 10.1038/s41598-023-45721-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo therapeutic interaction of selinexor and INCB057643 in a xenograft model of TP53-mutated HGBCL-DH. (A) Schematic showing the in vivo treatment plan. (B) Subcutaneous tumor volumes in the different treatment groups were recorded every two days throughout the treatment course. (C) Mouse body weights were monitored every other day. (D,E) Demonstration of tumor weights (left panel, D) and sizes (right panel, E) in the vehicle, selinexor, INCB057643 and combination regimen groups. (F) Assessment of tumor burden in distinct treatment groups using HE staining. (G) The TUNEL assay showed that the combination of selinexor with INCB057643 resulted in a higher apoptosis rate than that of either drug alone. *P < 0.05; **P < 0.01; ****P < 0.0001.