Table 2.

Therapeutic interventions prior to initiation of IVIG.

	Pre-IVIG PANS treatments	Additional pharmacologic interventions	Non-pharmacologic interventions
Patient 1	Abx, NSAIDs, Steroids	None	None
Patient 2	Abx, NSAIDs, Steroids	Guanfacine, SSRI	CBT, IEP
Patient 3	Abx, NSAIDs, Steroids	SSRI	Counseling
Patient 4	Abx, NSAIDs, Steroids	Lisdexamfetamine, SSRI	BT, 504 Plan, OT, ST
Patient 5	Abx, NSAIDs, Steroids	SSRIs, Atomoxetine, Amphetamine/dextroamphetamine	IEP, Counseling
Patient 6	Abx, NSAIDs, Steroids	Methylphenidate	504 Plan
Patient 7	Abx, NSAIDs, Steroids	None	None
Patient 8	Abx, NSAIDs, Steroids	SSRIs, Hydroxyzine, Aripiprazole, Trazodone	IEP, Counseling
Patient 9	Abx, NSAIDs, Steroids	SSRIs	BT, Counseling
Patient 10	Abx, Steroids	None	IEP, ABA, ST, OT
Patient 11	Abx, NSAIDs, Steroids	SSRI, Aripiprazole	CBT, Counseling
Patient 12	Abx, Nsaids, Steroids	Clonidine, Lisdexamfetamine	None

Abx, antibiotics; NSAIDs, non-steroidal anti-inflammatory drugs; steroids, prednisone 1 mg/kg for 5 days used in majority of patients; SSRI(s), selective serotonin reuptake inhibitor(s). In case of our patients this included: fluoxetine, fluvoxamine, sertraline, citalopram, escitalopram. IEP, individualized educational plan; ST, speech therapy; OT, occupational therapy; CBT, cognitive-behavioral therapy; BT, behavioral therapy; ABA, applied behavioral analysis.