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. 2023 Oct 16;14:1231937. doi: 10.3389/fimmu.2023.1231937

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Copyright © 2023 Chen, Jiang, Ding, Zhong, Li, Wan, Feng, Peng, Yang, Chen, Wang, Jiao, Yang, Chen, Li, Shi, Zhang, Wang, Yang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular characterization of CD4⁺ T cells in NS-IgAN. (A) 7 distinct subsets were visualized by UMAP plotting through re-clustering analysis of CD4⁺ T cells. (B) Violin plots showing expression of marker genes in 7 subsets. (C) UMAP plots showing color-coded expression of four representative markers, FOXP3, IL2RA, CCR7, and HLA-DRB1 in CD4⁺ T cells. (D) Heatmap exhibiting the differential expressing genes of Treg1 and Treg2. (E) The percent of Treg1 and Treg2 in CD4⁺ T cells. (F) GO terms identified by differential pathway enrichment and GO analysis via comparison of Treg2 cells vs. others. GO terms are labeled with name, and sorted by −log₁₀(P) value. A darker color indicates a smaller P value. Interesting terms are labeled in red. (G) Heatmap exhibiting DEGs of Treg2 in Con, NGC, SGC, and LGC.