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. 2023 Oct 16;14:1231937. doi: 10.3389/fimmu.2023.1231937

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Copyright © 2023 Chen, Jiang, Ding, Zhong, Li, Wan, Feng, Peng, Yang, Chen, Wang, Jiao, Yang, Chen, Li, Shi, Zhang, Wang, Yang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular characterization of interactions between kidney cells and kidney immune cells. (A) Cell-to-cell crosstalk networks between kidney cells in CTRL, HU-IgAN, NGC, and LGC groups. (B) Bubble chart showing dysregulated cell-type specific interactions between mesenchymal stromal cells (MSCs) and podocytes (PODs) or parietal epithelial cells (PECs) and podocytes (PODs) in the CTRL, HU-IgAN, NGC, and LGC group. (C) 8 cell subtypes were visualized by UMAP plotting through re-clustering analysis of kidney immune cells. (D) Violin plots showing marker genes of 8 kidney immune cell subtypes. (E) Developmental tree analysis showed the relationship between different kidney immune cells. (F) Cell trajectory map of lymphocytes showing the pseudo-time (Top). Ordering single cells along a cell conversion trajectory using Monocle 2. Three states were identified based on their distribution in the cell trajectory map (Bottom). (G) Heatmap: each column represents one cell and each row represents the expression of one gene. Cells are ordered by Monocle-based pseudotime analysis and the color represents expression levels. (H) The GO enrichment function items of cluster1-3 in (G) are shown by the bubble diagram.