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. 2023 Oct 16;14:1277120. doi: 10.3389/fimmu.2023.1277120

Figure 1.

Figure 1

Classification of innate lymphoid cells. ILCs are divided into three groups. ILC1s produce type 1 cytokines such as TNF and IFN-γ and express T-bet in response to IL-12, IL-15, and IL-18 stimulation. ILC2s are defined by the expression of RORγt and secretion of Th2-associated cytokines such as IL-4, IL-5, and IL-13. ILC3s express GATA3 and produce IL-17A and IL-22 in the stimulation setting by IL-1β, IL-23, and AHR ligands. AHR, aryl hydrocarbon receptor; Areg, amphiregulin; GM-CSF, granulocyte–macrophage colony-stimulating factor; IFN-γ, interferon-gamma; IL, interleukin; ILCs, innate lymphoid cells; LTD4, leukotriene D4; NK, natural killer; PGD2, prostaglandin D2; RANK, receptor activator of nuclear factor kappa B; Th, T helper; TNF, tumor necrosis factor; TSLP, thymic stromal lymphopoietin.