Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Illustration of the output of sensitivity analysis of PBK model. A sensitivity coefficient of 1 implies that a 1% change in parameter value (ie, input) leads to a 1% change in output (ie, Plasma Cmax and AUC predictions) of the model, indicating that the output is sensitive to that input parameter under the evaluated conditions. V, vehicle; SC, stratum corneum; E-epidermis, D-dermis, SB-sebum, PC-partition coefficient and W-water.
