Table 2.

Distribution of ¹⁴C-OMC after application to human skin (% Mean and standard deviation [SD])

Test Item	OMC
Six conditions: application terminated at:	30 min		1 h		2 h		4 h		8 h		24 h
	n = 5		n = 5		n = 5		n = 5		n = 5		n = 12
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Total strips (1–20)	0.51	0.14	0.30	0.13	0.73	0.20	0.37	0.21	0.50	0.18	0.41	0.17
Skin excessa	91.04	3.62	112.02	5.78	89.22	6.47	100.26	10.39	113.76	7.10	100.26	10.53
Epidermis	0.07	0.02	0.04	0.02	0.06	0.03	0.05	0.02	0.10	0.09	0.21	0.16
Dermis	0.004	0.01	0.01	0.01	0.005	0.01	0.01	0.01	0.01	0.01	0.02	0.01
Receptor fluid	0.02	0.05	0.003	0.01	0.04	0.02	0.06	0.04	0.09	0.05	0.06	0.08
Dermal deliveryb	0.10	0.05	0.06	0.03	0.11	0.06	0.12	0.05	0.20	0.14	0.28	0.17
Total recovery	91.65	3.64	112.38	5.74	90.06	6.29	100.75	10.47	114.46	6.85	100.96	10.56

^aSkin excess corresponds to: Washing + Donor compartment rinsing + Remaining skin.

^bDermal delivery is Epidermis + Dermis + Receptor fluid according to SCCS Notes of Guidance.