Table 3.
Distribution of 14C-octocrylene after application to human skin (%mean and SD) as reported in SCCS (2021)
| Test item | Octocrylene |
|
|---|---|---|
| Application terminated at: | 24 h (n = 12) |
|
| Mean | SD | |
| Total strips (1–20) | 0.69 | 0.31 |
| Skin excessa | 97.96 | 4.93 |
| Epidermis | 0.14 | 0.16 |
| Dermis | 0.012 | 0.016 |
| Receptor fluid | 0.0001 | 0.0003 |
| Dermal deliveryb | 0.15 | 0.17 |
| Total recovery | 98.8 | 4.92 |
a
Skin excess corresponds to: Washing + Donor compartment rinsing + Remaining skin.
b
Dermal delivery is Epidermis + dermis + receptor fluid according to SCCS Notes of Guidance.