Table 4.
Distribution of 4-MBC after application to pig skin (% Mean and SD) as reported in Sasson et al. (2009)
| Test item | 4-MBC |
|
|---|---|---|
| Application terminated at: | 24 h (n = 5)a |
|
| Mean | SD | |
| Skin excessb | 4.5 | 0.72 |
| Total strips (1–40) | 80.1 | 6.19 |
| Epidermis + Dermis | 2.9 | 0.5 |
| Receptor fluid | 0.25 | 0.03 |
| Dermal deliveryc | 3.17 | 0.53 |
| Total recovery | 87.8 | 6.9 |
a
At 8 h of postdosing, the skin surface was washed.
b
Skin excess corresponds to: Washing + Donor compartment rinsing + Remaining skin.
c
Dermal delivery is Epidermis + dermis + receptor fluid according to SCCS guideline.