Table 5.
Skin absorption parameters as input in the PBK models
| OMC | Octocrylene | 4-MBC | Source | |
|---|---|---|---|---|
| Vehicle/water partition coefficienta | 1.5E+05 | 4.0E+05 | 4.0E+04 | Fitted |
| Vehicle diffusivity (cm2/s) | 7.0E−12 | 6.2E−09 | 7.8E−06 | Fitted |
| Stratum corneum/water partition coefficient | 4.5E+02 | 2.0E+03 | 1.0E+03 | Fitted |
| Stratum corneum diffusivity (cm2/s) | 2.0E−10 | 2.0E−11 | 6.1E−11 | Fitted |
| Epidermis/water partition coefficient | 2.0E+01 | 6.0E+02 | 1.0E+02 | Fitted |
| Epidermis diffusivity (cm2/s) | 3.0E−08 | 2.0E−08 | 1.9E−09 | Fitted |
| Dermis/water partition coefficient | 7.0E−01 | 7.0E−01 | 2.0E+00 | Fitted |
| Dermis diffusivity (cm2/s) | 1.0E−07 | 6.0E−08 | 3.0E−08 | Fitted |
| Sebum/water partition coefficient | 5.5E+04 | 1.5E+05 | 5.4E+03 | Lian-Yangb |
| Sebum diffusivity (cm2/s) | 5.3E−08 | 1.6E−08 | 1.1E−07 | Lian-Yangb |
a
Vehicle/water partition coefficient is vehicle/formulation specific that when a different vehicle/formulation is used, this parameter may differ accordingly.
b
Lian-Yang method from GastroPlus.