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. 2015 Feb 25;2015(2):CD007079. doi: 10.1002/14651858.CD007079.pub3

Karandish 2003.

Methods Type of study: double‐blind, placebo‐controlled, randomised clinical trial.
Method of treatment allocation: no data.
Placebo: yes (starch tablets).
Intention‐to‐treat analyses: no, the initial number of participants were 77 pregnant women but by the end of study 68 participants remained.
 Losses to follow‐up: 11.7 % (9 in 77).
Participants Location: 2 prenatal clinics in county of Ahvaz, Iran.
Time frame: no data.
Eligible criteria: pregnant women between the ages of 18 to 35.
Pregnant women in their third trimester before week 28 of their pregnancies.
No history of abortion or stillbirth.
Not suffering from any metabolic or chronic diseases.
Not having previous history of giving birth to twins.
Not being on any other supplements with the exception of iron and folic acid.
Total recruited 77 pregnant women, treatment group, n = 33, placebo group, n = 35.
Interventions 1000 mg of calcium (2 capsules of 500 mg calcium carbonate) compared with placebo. The study started from 28th‐30th week gestation until delivery.
Outcomes Anthropometric parameters of neonates including weight, head circumference and length.
Notes This paper was written in Farsi. Dr Reza Navaei kindly translated it to English using the Cochrane Pregnancy and Childbirth Group's translation form.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Double‐blind, placebo‐controlled, randomised clinical trial were mentioned but there was no detail of sequencing generation.
Allocation concealment (selection bias) Unclear risk No detail in allocation concealment.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Randomised controlled trial. Placebo made by Manufacturer as the calcium capsules. Blinding of participants and staff.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk The trial was double blind. Patients and clinic staff were unaware of type of medicine.
Incomplete outcome data (attrition bias) 
 All outcomes High risk The initial participants were 77 pregnant women but the final analyses were 68 women. No details about 9 women who dropped out from the study.
Selective reporting (reporting bias) Low risk The preplanned outcomes were reported.
Other bias Low risk None identified.