Comparison 1. Calcimimetics versus placebo/no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	16	7351	Risk Ratio (IV, Random, 95% CI)	0.96 [0.89, 1.05]
1.1 GFR category G5 treated with dialysis	14	6893	Risk Ratio (IV, Random, 95% CI)	0.97 [0.89, 1.05]
1.2 GFR category G3a to G4	2	458	Risk Ratio (IV, Random, 95% CI)	0.29 [0.06, 1.48]
2 Cardiovascular mortality	9	5000	Risk Ratio (IV, Random, 95% CI)	0.68 [0.32, 1.45]
2.1 GFR category G5 treated with dialysis	7	4542	Risk Ratio (IV, Random, 95% CI)	0.67 [0.16, 2.87]
2.2 GFR category G3a to G4	2	458	Risk Ratio (IV, Random, 95% CI)	0.29 [0.06, 1.48]
3 Parathyroidectomy	5	4893	Risk Ratio (IV, Random, 95% CI)	0.49 [0.40, 0.59]
4 Fractures	2	3965	Risk Ratio (IV, Random, 95% CI)	0.52 [0.12, 2.27]
5 Hypocalcaemia	14	6864	Risk Ratio (IV, Random, 95% CI)	7.38 [5.43, 10.03]
5.1 GFR category G5 treated with dialysis	12	6415	Risk Ratio (IV, Random, 95% CI)	6.98 [5.10, 9.53]
5.2 GFR category G3a to G4	2	449	Risk Ratio (IV, Random, 95% CI)	31.90 [5.28, 192.60]
6 Hypercalcaemia	4	4662	Risk Ratio (IV, Random, 95% CI)	0.23 [0.05, 0.97]
7 Nausea	14	6899	Risk Ratio (IV, Random, 95% CI)	2.05 [1.54, 2.75]
7.1 GFR category G5 treated with dialysis	12	6450	Risk Ratio (IV, Random, 95% CI)	2.02 [1.45, 2.81]
7.2 GFR category G3a to G4	2	449	Risk Ratio (IV, Random, 95% CI)	2.26 [1.29, 3.95]
8 Vomiting	10	6718	Risk Ratio (IV, Random, 95% CI)	1.95 [1.74, 2.18]
8.1 GFR category G5 treated with dialysis	9	6323	Risk Ratio (IV, Random, 95% CI)	1.97 [1.73, 2.24]
8.2 GFR category G3a to G4	1	395	Risk Ratio (IV, Random, 95% CI)	1.77 [0.90, 3.48]
9 Diarrhoea	8	5639	Risk Ratio (IV, Random, 95% CI)	1.15 [1.02, 1.29]
10 Abdominal pain	4	831	Risk Ratio (IV, Random, 95% CI)	1.62 [0.55, 4.82]
11 Upper respiratory tract infection	4	1856	Risk Ratio (IV, Random, 95% CI)	0.95 [0.39, 2.33]
12 Asthenia, muscle weakness or paraesthesia	5	1379	Risk Ratio (IV, Random, 95% CI)	1.55 [0.93, 2.58]
12.1 Asthenia	2	790	Risk Ratio (IV, Random, 95% CI)	1.54 [0.26, 8.98]
12.2 Muscle weakness or paraesthesia	4	589	Risk Ratio (IV, Random, 95% CI)	1.78 [1.00, 3.14]
13 Dyspnoea	2	250	Risk Ratio (IV, Random, 95% CI)	1.02 [0.49, 2.12]
14 Headache	3	1115	Risk Ratio (IV, Random, 95% CI)	1.11 [0.65, 1.91]
15 Achievement of PTH target	11	2853	Risk Ratio (IV, Random, 95% CI)	3.06 [1.89, 4.98]
16 PTH	7	1935	Mean Difference (IV, Random, 95% CI)	‐280.39 [‐325.84, ‐234.94]
17 Serum calcium	7	1556	Mean Difference (IV, Random, 95% CI)	‐0.87 [‐0.96, ‐0.77]
18 Serum phosphorous	8	2300	Mean Difference (IV, Random, 95% CI)	‐0.23 [‐0.58, 0.12]
19 Calcium x phosphorous	8	2395	Mean Difference (IV, Random, 95% CI)	‐5.25 [‐9.16, ‐1.34]