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. 2023 May 25;108(10):2664–2676. doi: 10.3324/haematol.2022.281869

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Figure 3. — Gene expression in chronic lymphocytic leukemia with trisomy 12. (A) Role of dosage effect: chromosomal distribution of differentially expressed (DE) genes in chronic lymphocytic leukemia (CLL) with trisomy 12. Chromosome 12 has the highest number of DE genes, but the majority of DE genes is distributed across all chromosomes and cannot be ascribed to a dosage effect. (B) DE genes in enriched KEGG pathways of trisomy 12. (C-E) Normalized gene counts of VAV1, CTLA4 and NT5E.