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. 2023 Oct 10;66(20):13991–14010. doi: 10.1021/acs.jmedchem.3c01035

Table 3. Uptake of [18F]RM365 into the hCB2R(D80N) Overexpressing Right Striatum Normalized to the Contralateral Left Striatum and Cerebellum (SUV Ratio, SUVr) With (n = 3) or Without (vehicle, n = 3) Administration of GW405833 (5 mg/kg Bodyweight, i.v.) at 20 min After Radiotracer Administration, Expressed as Area under the Curve Before (AUC0-20 min) and After (AUC20-60 min) Injection of the Interventional Drug.

hCB2R D80N-to- treatment AUC0–20 min (CI95%) in SUVr·min AUC20–60 min (CI95%) in SUVr·min
contralateral vehicle 55 (42–68) 419 (288–550)
  displacement 49 (44–54) 151 (125–177) – 63.9%
cerebellum vehicle 60 (45–75) 543 (384–703)
  displacement 65 (59–71) 164 (150–178) – 69.8%

Mean; 95% confidence interval (CI95%).