Table 3. Uptake of [18F]RM365 into the hCB2R(D80N) Overexpressing Right Striatum Normalized to the Contralateral Left Striatum and Cerebellum (SUV Ratio, SUVr) With (n = 3) or Without (vehicle, n = 3) Administration of GW405833 (5 mg/kg Bodyweight, i.v.) at 20 min After Radiotracer Administration, Expressed as Area under the Curve Before (AUC0-20 min) and After (AUC20-60 min) Injection of the Interventional Drug.
| hCB2R D80N-to- | treatment | AUC0–20 min (CI95%) in SUVr·min | AUC20–60 min (CI95%) in SUVr·min |
|---|---|---|---|
| contralateral | vehicle | 55 (42–68) | 419 (288–550) |
| displacement | 49 (44–54) | 151 (125–177) – 63.9% | |
| cerebellum | vehicle | 60 (45–75) | 543 (384–703) |
| displacement | 65 (59–71) | 164 (150–178) – 69.8% |
Mean; 95% confidence interval (CI95%).