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Validating effects of factors on TA biogenesis. (A) Integration of the TA proteins SEC61β -GFP11 or SQS-GFP11 into the ER was assessed in K562 cells that expressed the indicated programmed dual guides. GFP fluorescence is shown relative to a normalization marker (RFP) as determined by flow cytometry, and the results displayed as a histogram. (B) Biogenesis of SEC61β-GFP11 was assessed as in (A) with the presence of guides targeting the indicated genetic targets
