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. 2023 Oct 30;21:299. doi: 10.1186/s12964-022-00872-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — HnRNPA1 mediated miR-23a-3p packaging into M2 macrophage-derived exosomes. a, b Knockdown of hnRNPA1 was assessed by qRT-PCR and western blotting. c The effect of hnRNPA1 knock down of the expression of miR-23a-3p in M2 macrophage exosomes as analyzed by RT-PCR. d The combination of miR-23a-3p and hnRNPA1 was evaluated by the RIP assay. e The expression of miR-23a-3p in HCC cells and HUVECs when cocultured with M2 macrophages after hnRNPA1 knock down and assessed by RT-PCR. f The effect of M2 macrophage exosomes after hnRNPA1 knock down on HCC cell metastasis and evaluated by a Transwell^Ò assay. *P < 0.05, **P < 0.01, ***P < 0.001. g.The effect of M2 macrophage derived exosomes after hnRNPA1 knock down on HCC cell migratory ability as assessed by the scratch assay