Table 2.
Comparison of 18F-FDG PET/CT and 18F-FAPI PET/CT for the intrahepatic lesions of 67 patients
| Description of lesions | No. of patients (No. of lesions) | 18F-FDG PET/CT | 18F-FAPI PET/CT |
P value (FDG vs. FAPI) |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Positive detection of lesions(%) | Median SUVmax (range) | Median TBR (range) | Positive detection of lesions(%) | Median SUVmax (range) | Median TBR (range) | SUVmax | TBR | ||
| Total | 67 | 35(52.2%) | 5.3(2.3–22.5) | 2.1(1.0–15.2) | 66(98.5%) | 9.9(0.4–24.1) | 6.0(0.8–30.0) | < 0.0001 | < 0.0001 |
| Primary Tumor | 59 | 31(53.4%) | 5.6(2.3–22.5) | 2.2(1.0–15.2) | 58(98.3%) | 9.9(0.4–24.1) | 6.7(0.8–30.0) | < 0.0001 | < 0.0001 |
| T1 | 16 | 5(31.3%) | 3.75(2.3–11.2) | 1.5(1.0–4.3) | 15(93.8%) | 4.65(0.4–15.2) | 3.6(0.8–27.8) | 0.1305 | < 0.0001 |
| T2 | 13 | 5(38.5%) | 5.3(2.3–22.5) | 1.7(1.4–9.8) | 13(100%) | 9.9(4.6–15.6) | 5.0(1.5–15.0) | 0.0339 | 0.0002 |
| T3 | 14 | 5(35.7%) | 5.5(3.7–15.5) | 2.1(1.3–6.4) | 14(100%) | 10.9(3.3–24.1) | 6.6(2.6–30.0) | 0.0085 | 0.0001 |
| T4 | 16 | 16(100%) | 14.5(4.1–18.4) | 3.5(1.9–15.2) | 16(100%) | 12.9(2.2–22.9) | 10.2(4.1–22.5) | 0.0457 | < 0.0001 |
| Recurrent Tumor | 8 | 4(50.0%) | 3.6(2.4–11.8) | 1.4(1.0–5.2) | 8(100%) | 9.8(2.9–16.8) | 5.4(2.6–12.9) | 0.0781 | 0.0078 |
| Tumor Size(cm) | |||||||||
| Total | 67(258) | 106(41.1%) | 4.3(1.3–22.5) | 1.7(0.5–15.2) | 238(92.2%) | 6.7(0.4–24.1) | 3.9(0.8–30.0) | < 0.0001 | < 0.0001 |
| ≤ 2 | NA(110) | 28(25.5%) | 3.7(1.3–9.8) | 1.5(0.5–4.3) | 97(88.1%) | 5.9(1.2–18.3) | 3.1(0.8–22.9) | < 0.0001 | < 0.0001 |
| > 2, ≤ 5 | NA(89) | 34(38.2%) | 4.2(2.2–13.8) | 1.6(0.8–10.3) | 82(92.1%) | 6.5(0.4–22.4) | 3.8(0.8–30.0) | < 0.0001 | < 0.0001 |
| > 5 | NA(59) | 44(74.6%) | 7.1(3.7–22.5) | 2.5(1.3–15.2) | 59(100%) | 11.2(2.2–24.1) | 6.6(2.6–26.1) | < 0.0001 | < 0.0001 |
| No. of lesions | |||||||||
| Solitary | 32(32) | 12(37.5%) | 4.35(2.3–22.5) | 1.7(1.0–9.8) | 31(96.9%) | 6.35(0.4–15.6) | 5.15(0.8–27.8) | 0.0152 | < 0.0001 |
| Multifocal | 35(226) | 94(41.6%) | 4.3(1.3–18.4) | 1.7(0.5–15.2) | 207(91.6%) | 6.7(1.2–24.1) | 3.8(0.8–30.0) | < 0.0001 | < 0.0001 |
| Macrovascular invasion | 18(18) | 18(100%) | 5.6(2.7–23.3) | 3.5(1.4–12.3) | 16(88.9%) | 4.65(0.5–8.2) | 2.9(1.2–4.6) | 0.007 | 0.043 |
Bold fonts indicate significant difference between FDG and FAPI (P < 0.05)
18F Fluorine 18, FDG fluorodeoxyglucose, FAPI fibroblast activation protein inhibitor, PET/CT positron emission tomography/computed tomography, HCC hepatocellular carcinoma, SUVmax maximum standardized uptake value, TBR Tumor-to-background ratio, NA Not applicable