Table 3.
Comparison of 18F-FDG PET/CT and 18F-FAPI PET/CT for the extrahepatic lesions
| Description of lesions | No. of patients (No. of lesions) | 18F-FDG PET/CT | 18F-FAPI PET/CT |
P value (FDG vs. FAPI) |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Positive detection of lesions(%) | Median SUVmax (range) | Median TBR (range) | Positive detection of lesions(%) | Median SUVmax (range) | Median TBR (range) | SUVmax | TBR | ||
| Lymph node metastasis | 7(129) | 115(89.1%) | 7.6(1.2–20.7) | 4.5(0.5–17.3) | 126(97.9%) | 7.3(2.0–21.8) | 6.3(1.4–26.5) | 0.7475 | < 0.0001 |
| Head and neck regions | 3(16) | 13(81.3%) | 4.8(1.2–14.7) | 2.1(0.5–9.2) | 16(100%) | 7.7(3.0–13.9) | 5.2(1.5–17.4) | 0.0148 | < 0.0001 |
| Thoracic regions | 2(15) | 15(100%) | 11.5(3.1–16.4) | 7.2(1.3–10.3) | 15(100%) | 13.1(8.5–21.2) | 16.4(4.7–26.5) | 0.0267 | < 0.0001 |
| Abdominal regions | 7(86) | 81(94.2%) | 7.95(1.8–20.7) | 4.9(0.8–17.3) | 83(96.5%) | 6.9(2.0–21.8) | 5.3(1.4–16.9) | 0.0772 | 0.2818 |
| Pelvic regions | 2(12) | 6(50%) | 2.8(1.7–10.6) | 1.3(0.8–6.6) | 12(100%) | 7.1(3.0–13.8) | 7.4(2.3–10.6) | 0.1763 | 0.0005 |
| Lymph node size(cm) | |||||||||
| ≤ 1 | NA(65) | 51(78.5%) | 5.2(1.2–16.7) | 3.3(0.5–13.9) | 62(95.4%) | 6.2(2.0–21.8) | 5.0(1.4–23.1) | 0.1253 | 0.0016 |
| > 1 | NA(64) | 64(100%) | 10.55(3.1–20.7) | 6.75(1.3–17.3) | 64(100%) | 9.35(3.1–21.2) | 10.15(2.0–26.5) | 0.3771 | 0.0004 |
| Distant lesions | 9(66) | 46(69.7%) | 5.0(0.7–25.4) | 6.5(0.6–84.7) | 42(63.6%) | 2.75(0.5–20.4) | 7.45(1.7–30.0) | 0.0139 | 0.582 |
| Lung | 6(24) | 7(29.1%) | 1.4(0.7–10.2) | 6.5(3.5–51.0) | 8(37.5%) | 1.65(0.5–10.5) | 13.0(1.7–28.0) | 0.7196 | 0.0639 |
| Bone | 3(24) | 24(100%) | 11.1(5.2–25.4) | 24.15(2.9–84.7) | 16(66.7%) | 3.0(1.1–20.4) | 6.3(2.8–30.0) | 0.0007 | 0.0014 |
| Peritoneal | 1(17) | 14(82.4%) | 3.9(1.3–7.7) | 1.7(0.6–3.3) | 17(100%) | 4.8(2.3–7.0) | 5.3(2.6–7.8) | 0.0731 | < 0.0001 |
| Adrenal gland | 1(1) | 1(100%) | 5.6(NA) | 1.9(NA) | 1(100%) | 4.8(NA) | 4.8(NA) | - | - |
| Total | 13(195) | 161(82.6%) | 6.3(0.7–25.4) | 5.1(0.5–84.7) | 168(86.2%) | 6.4(0.5–21.8) | 6.6(1.4–30.0) | 0.2538 | 0.0007 |
Bold fonts indicate significant difference between FDG and FAPI (P < 0.05)
18F Fluorine 18, FDG fluorodeoxyglucose, FAPI fibroblast activation protein inhibitor, PET/CT positron emission tomography/computed tomography, HCC hepatocellular carcinoma, SUVmax maximum standardized uptake value, TBR Tumor-to-background ratio, NA Not applicable