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. Author manuscript; available in PMC: 2023 Oct 30.
Published in final edited form as: J Autoimmun. 2022 Aug 18;132:102882. doi: 10.1016/j.jaut.2022.102882

Table 3.

Multifactor dimensionality reduction (MDR) analysis in the Turkish cohort providing confirming evidence for interaction between sex and susceptibility loci in Behçet’s disease.
MDR Analysis
Locus SNP Cross-validation consistency Balanced Accuracy χ2 P-value
HLA-B/MICA rs116799036 10/10 0.56 30.76 2.92 × 10−8
HLA-C rs12525170 10/10 0.56 31.81 1.7 × 10−8
KLRC4 rs2617170 10/10 0.52 4.26 0.039
IFNGR1 rs4896243 10/10 0.52 5.23 0.019

Cross-validation consistency is a measure of the number of times the same MDR model is identified in each possible 90% of the subjects [31]; Balanced Accuracy is defined as (sensitivity + specificity/2). Sensitivity represents true positive rate (true positives/(true positives + false negatives)), and specificity represents true negative rate (true negatives/(false positives + true negatives)). Balanced accuracy is used as an estimator of true accuracy to mitigate imbalanced sampling [34].Degree of freedom (df) of 1 was used to calculate the P Values from χ2. SNP, single nucleotide polymorphism.