Table 1.

Summary of all statistical methods

Section	Procedure	Method
Lifetime comorbidity	Association of reproductive disorders with each other and with female MD, PND, and NPD	Logistic regression using R version 4.0.5, including age as a covariate for female MD, and age and number of births as covariates for PND and NPD
Genetic analysis of reproductive disorders	Conducting GWAS for each reproductive disorder and depression group	FastGWA-binary [29]
	Assessing SNP-based heritability for each reproductive disorder	Haseman-Elston method [30]
	Meta-analyses of reproductive disorders using UKB and FinnGen summary statistics	Metal [33], using fixed effects, standard error-based model
	Downstream analyses of GWAS summary statistics: Identification of significant loci and significantly associated genes/tissues	All summary statistics submitted to FUMA [34], which utilises MAGMA [35] for gene-based testing
	Genetic correlations between reproductive disorders, and between reproductive disorders and depression groups	LDSC [37] used with GWAS summary statistics for calculation of genetic correlations
Identifying underlying latent factor structure	Identifying latent factor structure	GenomicSEM [19] used to develop a model of an underlying genetic factor for 5 reproductive disorders
	Downstream analysis of latent factor summary statistics	Summary statistics submitted to FUMA [34], stratified LDSC used to identify regions of enhanced heritability and tissues enriched in expression of associated genes
	Genetic correlations between latent factor and depression groups	LDSC [37] used with summary statistics for calculation of genetic correlations