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Model of Vg1-Nodal heterodimer formation and processing. Maternal Vg1 is retained in the ER via chaperone-binding motifs; during maternal-zygotic transition, Nodal is produced and induces release of Vg1 from the ER via heterodimer formation; processing of the Vg1 prodomain is required for the activity of Vg1-Nodal heterodimers but can be independent from dimer formation and secretion.
